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Mouse Anti-Human CD95-LE/AF (DX3)
Cat. No.:
9735-14
Low Endotoxin/Azide Free Anti-Human CD95 antibody for use in flow cytometry, ELISA, immunohistochemistry assays.
$380.00
| Clone | DX3 |
|---|---|
| Isotype | Mouse (C3H/He) IgG2aκ |
| Isotype Control | Mouse IgG2a-LE/AF (HOPC-1) |
| Specificity | Human/Rat CD95 |
| Alternative Names | APO-1, Fas, TNFRSF6 |
| Description | CD95, also known as Fas and APO-1, is a 45 kDa type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It is expressed by activated lymphocytes, monocytes, neutrophils, fibroblasts, and cell lines. Fas ligand binding to CD95 induces apoptosis in activated mature lymphocytes thereby playing a role in maintaining peripheral tolerance. |
| Immunogen | Human CD95 transfected L cells |
| Conjugate | LE/AF (Low Endotoxin/Azide Free) |
| Buffer Formulation | Phosphate buffered saline, pH 7.4 |
| Clonality | Monoclonal |
| Concentration | 0.5 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C; Handle under aseptic conditions |
| Applications | Flow Cytometry – Quality tested 1 Immunohistochemistry-Paraffin Sections – Reported in literature 2,3 ELISA – Reported in literature 4 |
| RRID Number | AB_2797090 |
| Gene ID | 355 (Human) 246097 (Rat) |
| Gene ID Symbol | FAS (Human) Fas (Rat) |
| Gene ID Aliases | ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6; Tnfrsf6 |
| UniProt ID | P25445 (Human Q63199 (Rat |
| UniProt Name | TNR6_HUMAN (Human) TNR6_RAT (Rat) |
Documentation
Certificate of Analysis Lookup
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- 1. Lanier LL, Chang C, Phillips JH. Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes. J Immunol. 1994;153:2417-28. (Immunogen, FC)
- 2. Jacob T, Ascher E, Hingorani A, Kallakuri S. Glycine prevents the induction of apoptosis attributed to mesenteric ischemia/reperfusion injury in a rat model. Surgery. 2003;134:457-66. (IHC-PS, Rat Reactivity)
- 3. Miñambres E, Ballesteros MA, Mayorga M, Marin MJ, Muñoz P, Figols J, et al. Cerebral apoptosis in severe traumatic brain injury patients: an in vitro, in vivo, and postmortem study. J Neurotrauma. 2008;25:581-91. (IHC-PS)
- 4. Jodo S, Kobayashi S, Kayagaki N, Ogura N, Feng Y, Amasaki Y, et al. Serum levels of soluble Fas/APO-1 (CD95) and its molecular structure in patients with systemic lupus erythematosus (SLE) and other autoimmune diseases. Clin Exp Immunol. 1997;107:89-95. (ELISA)
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