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Mouse Anti-Human CD51-UNLB (13C2)
Cat. No.:
9656-01
Purified Anti-Human CD51 antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, ELISA, purification, depletion, adhesion, and blocking assays.
$108.00
| Clone | 13C2 |
|---|---|
| Isotype | Mouse (BALB/c) IgG1κ |
| Isotype Control | Mouse IgG1-UNLB (15H6) |
| Specificity | Human/African Green Monkey/Rabbit/Bovine CD51 |
| Alternative Names | Integrin αV, vitronectin receptor, VNR-α chain |
| Description | CD51 represents the integrin αV chain that associates with integrin β3 (CD61) to form the CD51/CD61 vitronectin receptor on endothelial cells, certain activated leukocytes, NK cells, macrophages, neutrophils, and platelets. CD51 is the most promiscuous integrin α subunit as it can form heterodimers with the β1 (CD29), β3 (CD61), β5, β6 and β8 subunits in various tissues. CD51/CD61 acts as an activation-independent receptor for platelet attachment and spreading on vitronectin and other RGD-containing proteins including matrix components. It also mediates leukocyte-endothelial cell adhesion via interaction with CD31. |
| Immunogen | Cell suspension containing osteoclasts from osteoclastomas |
| Conjugate | UNLB (Unconjugated) |
| Buffer Formulation | Borate buffered saline, pH 8.2 |
| Clonality | Monoclonal |
| Concentration | 0.1 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C |
| Applications | Flow Cytometry – Quality tested 7,9,10 Immunohistochemistry-Frozen Sections – Reported in literature 1,5 Immunocytochemistry – Reported in literature 3 Immunoprecipitation – Reported in literature 2,3,5,9 ELISA – Reported in literature 8 Purification – Reported in literature 4,5 Depletion – Reported in literature 7 Blocking – Reported in literature 3,6 Adhesion – Reported in literature 3 |
| RRID Number | AB_2797043 |
| Gene ID | 3685 (Human) 103217487 (Green Monkey) 100008956 (Rabbit) 281875 (Bovine) |
| Gene ID Symbol | ITGAV (Human) ITGAV (Green Monkey) ITGAV (Rabbit) ITGAV (Bovine) |
| Gene ID Aliases | CD51; MSK8; VNRA; VTNR |
| UniProt ID | P06756 (Human P80746 (Bovine |
| UniProt Name | ITAV_HUMAN (Human) ITAV_BOVIN (Bovine) |
Documentation
Certificate of Analysis Lookup
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- 1. Horton MA, Lewis D, McNulty K, Pringle JA, Chambers TJ. Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens. Cancer Res. 1985;45:5563-9. (Immunogen, IHC-FS)
- 2. Bates RC, Bellovin DI, Brown C, Maynard E, Wu B, Kawakatsu H, et al. Transcriptional activation of integrin β6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest. 2005;115:339-47. (IP)
- 3. Adams JC, Watt FM. Expression of β1, β3, β4, and β5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes. J Cell Biol. 1991;115:829-41. (IP, ICC, Block, Adhesion)
- 4. Nesbitt S, Nesbit A, Helfrich M, Horton M. Biochemical characterization of human osteoclast integrins. Osteoclasts express αvβ3, α2β1, and αvβ1 integrins. J Biol Chem. 1993;268:16737-45. (Purification)
- 5. Davies J, Warwick J, Totty N, Philip R, Helfrich M, Horton M. The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor. J Cell Biol. 1989;109:1817-26. (IP, Purification, IHC-FS, African Green Monkey & Rabbit Reactivity)
- 6. Janes SM, Watt FM. Switch from αvβ5 to αvβ6 integrin expression protects squamous cell carcinomas from anoikis. J Cell Biol. 2004;166:419-31. (Block)
- 7. Pasqualini R, Bodorova J, Ye S, Hemler ME. A study of the structure, function and distribution of β5 integrins using novel anti-β5 monoclonal antibodies. J Cell Sci. 1993;105:101-11. (Depletion, FC)
- 8. Andreesen R, Brugger W, Scheibenbogen C, Kreutz M, Leser H, Rehm A, et al. Surface phenotype analysis of human monocyte to macrophage maturation. J Leukoc Biol. 1990;47:490-7. (ELISA)
- 9. Wong DA, Springer TA. Adhesion structure subpanels 7 and 8, β3, β4, β7 integrins and novel functional antigens: CD51, CD61, CD103, and CD104. In: Schlossman SF, Boumsell L, Gilks W, Harlan JM, Kishimoto T, Morimoto C, et al, editors. Leukocyte Typing V: White Cell Differentiation Antigens. Oxford: Oxford University Press; 1995. p. 1655-9. (IP, FC, Bovine Reactivity)
- 10. Gravelle S, Barnes R, Hawdon N, Shewchuk L, Eibl J, Lam JS, et al. Up-regulation of integrin expression in lung adenocarcinoma cells caused by bacterial infection: in vitro study. Innate Immun. 2010;16:14-26. (FC)
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