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Mouse Anti-Human CD42b-LE/AF (MM2/174)
Cat. No.:
9615-14
Low Endotoxin/Azide Free Anti-Human CD42b antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blot, and immunoprecipitation assays.
$314.00
| Clone | MM2/174 |
|---|---|
| Isotype | Mouse IgG1κ |
| Isotype Control | Mouse IgG1-LE/AF (15H6) |
| Specificity | Human CD42b |
| Alternative Names | GPIbα, glycocalicin |
| Description | CD42b, also known as GPIbα, is a two-chain membrane glycoprotein that forms a noncovalent complex with CD42a (GPIX) on the surface of platelets and megakaryocytes. Binding of the GPIb/GPIX heterodimer to von Willebrand factor bound to exposed subendothelial surfaces is essential for platelet adhesion at sites of injury. |
| Immunogen | Human plasma membrane |
| Conjugate | LE/AF (Low Endotoxin/Azide Free) |
| Buffer Formulation | Phosphate buffered saline, pH 7.4 |
| Clonality | Monoclonal |
| Concentration | 0.5 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C; Handle under aseptic conditions |
| Applications | Flow Cytometry – Quality tested 5,6 Immunohistochemistry-Frozen Sections – Reported in literature 2 Immunohistochemistry-Paraffin Sections – Reported in literature 3,4 Immunocytochemistry – Reported in literature 2 Immunoprecipitation – Reported in literature 1 Western Blot – Reported in literature 3 |
| RRID Number | AB_2797006 |
| Gene ID | 2811 (Human) |
| Gene ID Symbol | GP1BA (Human) |
| Gene ID Aliases | BDPLT1; BDPLT3; BSS; CD42B; CD42b-alpha; DBPLT3; GP1B; GPIbA; GPIbalpha; VWDP |
| UniProt ID | P07359 (Human |
| UniProt Name | GP1BA_HUMAN (Human) |
Documentation
Certificate of Analysis Lookup
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- 1. Yajima A, Takahashi Y, Konishi K. Identification of platelet receptors for the Streptococcus gordonii DL1 sialic acid-binding adhesin. Microbiol Immunol. 2005;49:795-800. (IP)
- 2. Parravicini CL, Soligo D, Berti E, Cattoretti G, Gaiera G, Vago L. Immunohistochemical reactivity of anti-platelet mAb in normal human tissues and bone marrow. In: Knapp W, Dörken B, Gilks WR, Rieber EP, Schmidt RE, Stein H, et al, editors. Leukocyte Typing IV: White Cell Differentiation Antigens. Oxford: Oxford University Press; 1989. p. 981-5. (IHC-FS, ICC)
- 3. Mäyränpää MI, Reséndiz JC, Heikkilä HM, Lindstedt KA, Kovanen PT. Improved identification of endothelial erosion by simultaneous detection of endothelial cells (CD31/CD34) and platelets (CD42b). Endothelium. 2007;14:81-7. (WB, IHC-PS)
- 4. Ishigaki H, Miyauchi J, Yokoe A, Nakayama M, Yanagi T, Taga T, et al. Expression of megakaryocytic and myeloid markers in blasts of transient abnormal myelopoiesis in a stillbirth with Down syndrome: report of histopathological findings of an autopsy case. Hum Pathol. 2011;42:141-5. (IHC-PS)
- 5. Zamai L, Secchiero P, Pierpaoli S, Bassini A, Papa S, Alnemri ES, et al. TNF-related apoptosis-inducing ligand (TRAIL) as a negative regulator of normal human erythropoiesis. Blood. 2000;95:3716-24. (FC)
- 6. Heindl B, Zahler S, Welsch U, Becker BF. Disparate effects of adhesion and degranulation of platelets on myocardial and coronary function in postischaemic hearts. Cardiovasc Res. 1998;38:383-94. (FC)
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