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Mouse Anti-Chicken CD1.1-FITC (CB3)
Cat. No.:
8430-02
FITC Anti-Chicken CD1.1 antibody for use in flow cytometry and immunohistochemistry / immunocytochemistry assays.
$374.00
| Clone | CB3 |
|---|---|
| Isotype | Mouse (BALB/c) IgG1κ |
| Isotype Control | Mouse IgG1-FITC (15H6) |
| Specificity | Chicken CD1.1 |
| Description | CD1 molecules, like MHC I and II, play an important role in the immune system by presenting lipid, glycolipid and lipopeptide antigen to T and NKT cells. The chicken CD1 gene is located in the chicken MHC B locus and has an important implication for the primordial MHC gene evolution. Two proteins have been identified - CD1.1 and CD1.2. Analysis of RNA from blood cells showed that both genes are expressed in Bu-1+ cells and CD8α+ cells. CD1.2 is expressed in TCRγδ cells but is nearly undetectable in TCRαβ. The monoclonal antibody CB3 antibody can identify cells of the B cell lineage and recognizes CD1.1 but not CD1.2 on the surface of transfected mammalian cells. |
| Immunogen | Lymphocytes from the bursa of Fabricius of outbred chickens |
| Conjugate | FITC (Fluorescein) |
| Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide |
| Clonality | Monoclonal |
| Concentration | 0.5 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C; Avoid exposure to light |
| Applications |
Flow Cytometry – Quality tested 1-3 Immunohistochemistry-Frozen Sections – Reported in literature 1 Immunocytochemistry – Reported in literature 1 Immunoprecipitation – Reported in literature 1 |
| RRID Number | AB_2796570 |
| Gene ID |
425801 (Chicken) |
| Gene ID Symbol |
CD1C (Chicken) |
| Gene ID Aliases | CD1D; CD1.1; CD1.2; CD1A1 |
Documentation
Certificate of Analysis Lookup
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- 1. Pickel JM, Chen CH, Cooper MD. An avian B-lymphocyte protein associated with β2-microglobulin. Immunogenetics. 1990;32:1-7. (Immunogen, FC, IHC-FS, ICC, IP)
- 2. Salomonsen J, Sørensen MR, Marston DA, Rogers SL, Collen T, van Hateren A, et al. Two CD1 genes map to the chicken MHC, indicating that CD1 genes are ancient and likely to have been present in the primordial MHC. Proc Natl Acad Sci USA. 2005;102:8668-73. (FC)
- 3. Wu Z, Rothwell L, Young JR, Kaufman J, Butter C, Kaiser P. Generation and characterization of chicken bone marrow-derived dendritic cells. Immunology. 2009;129:133-45. (FC)
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