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Mouse Anti-Mouse CD72.1-APC (10.1.D2)
Cat. No.:
1725-11
APC Anti-Mouse CD72.1 antibody for use in flow cytometry assays.
$270.00
| Clone | 10.1.D2 |
|---|---|
| Isotype | Mouse (C57BL/6) IgG2bκ |
| Isotype Control | Mouse IgG2b-APC (A-1) |
| Specificity | Mouse CD72.1 |
| Alternative Names | Lyb-2.1, CD72a, Lyb-2a |
| Description | Murine CD72.1 (Lyb-2.1), a type II integral membrane glycoprotein and a member of the C-lectin family of cell surface receptors, is a differentiation antigen of B cells and is found in mouse strains expressing the Lyb-2.1 allotype. CD72.1 is the ligand of CD5 which is distributed on all T cells and a small number of B cells. The 10.1.D2 monoclonal antibody blocks binding of CD5 to CD72 on the B cell surface which leads to inhibition of the positive signal resulting from CD5/CD72 pairing. However, 10.1.D2 can itself trigger a positive signal by binding CD72. |
| Immunogen | DBA/2 mouse spleen cells |
| Conjugate | APC (Allophycocyanin) |
| Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide and a stabilizer |
| Clonality | Monoclonal |
| Concentration | 0.1 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C; Avoid exposure to light; Do not freeze |
| Applications |
Flow Cytometry – Quality tested 1,4-6 Immunoprecipitation – Reported in literature 2 Activation – Reported in literature 1 Blocking – Reported in literature 5 Costimulation – Reported in literature 3 |
| RRID Number | AB_2795199 |
| Gene ID |
12517 (Mouse) |
| Gene ID Symbol |
Cd72 (Mouse) |
| Gene ID Aliases | CD72c; Ly-19; Ly-32; Lyb-2; Ly-m19 |
| UniProt ID |
P21855 (Mouse |
| UniProt Name |
CD72_MOUSE (Mouse) |
Documentation
Certificate of Analysis Lookup
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- 1. Subbarao B, Mosier DE. Induction of B lymphocyte proliferation by monoclonal anti-Lyb 2 antibody. J Immunol. 1983;130:2033-7. (Immunogen, FC, Activ)
- 2. Robinson WH, Landolfi MM, Schäfer H, Parnes JR. Biochemical identity of the mouse Ly-19.2 and Ly-32.2 alloantigens with the B cell differentiation antigen Lyb-2/CD72. J Immunol. 1993;151:4764-72. (IP)
- 3. Snow EC, Mond JJ, Subbarao B. Enhancement by monoclonal anti-Lyb-2 antibody of antigen-specific B lymphocyte expansion stimulated by TNP-Ficoll and T lymphocyte-derived factors. J Immunol. 1986;137:1793-6. (Costim)
- 4. Robinson WH, Ying H, Miceli MC, Parnes JR. Extensive polymorphism in the extracellular domain of the mouse B cell differentiation antigen Lyb-2/CD72. J Immunol. 1992;149:880-6. (FC)
- 5. Luo W, van de Velde H, von Hoegen I, Parnes JR, Thielemans K. Ly-1 (CD5), a membrane glycoprotein of mouse T lymphocytes and a subset of B cells, is a natural ligand of the B cell surface protein Lyb-2 (CD72). J Immunol. 1992;148:1630-4. (Block, FC)
- 6. Zhu Z, Li R, Li H, Zhou T, Davis RS. FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling. Proc Natl Acad Sci USA. 2013;110:E1282-90. (FC)
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