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Mouse Anti-Human IL-31-BIOT (SB118b)
Cat. No.:
15630-08
Biotin Anti-Human IL-31 antibody for use in ELISA assays.
$297.00
| Clone | SB118b |
|---|---|
| Isotype | Mouse (BALB/c) IgG2bκ |
| Isotype Control | Mouse IgG2b-BIOT (A-1) |
| Specificity | Human IL-31 |
| Alternative Names | Interleukin-31 |
| Description | Interleukin-31 (IL-31) is a 24 kDa α-helical protein and a member of the IL-6 family of cytokines that is preferentially expressed by CD4+ T cells. This cytokine elicits its response by binding to a heterodimeric complex consisting of a gp130-like receptor chain and the oncostatin M receptor subunit. On target cells which include a broad range of immune and non-immune cells, IL-31 binding can induce activation of the Jak/STAT, AKT, and MAPK signaling pathways. Due to the ubiquitous expression of its receptor complex, IL-31 has numerous physiological roles that include regulating hematopoiesis and immune response. Over-expression has been linked to chronic inflammatory states such as dermatitis, pruritus, airway hypersensitivity, and inflammatory bowel disease. |
| Immunogen | E. coli-expressed human IL-31 |
| Conjugate | BIOT (Biotin) |
| Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide |
| Clonality | Monoclonal |
| Concentration | 0.5 mg/mL |
| Volume | 0.2 mL |
| Recommended Storage | 2-8°C |
| Applications | ELISA – Quality tested |
| RRID Number | AB_2794927 |
| Gene ID | 386653 (Human) |
| Gene ID Symbol | IL31 (Human) |
| Gene ID Aliases | IL-31 |
| UniProt ID | Q6EBC2 (Human |
| UniProt Name | IL31_HUMAN (Human) |
Documentation
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