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Rat Anti-Mouse CD5-BIOT (4H8E5)
Cat. No.:
1546-08
Biotin Anti-Mouse CD5 antibody for use in flow cytometry assays.
$275.00
| Clone | 4H8E5 |
|---|---|
| Isotype | Rat IgG2aκ |
| Isotype Control | Rat IgG2a-BIOT (KLH/G2a-1-1) |
| Specificity | Mouse CD5 |
| Alternative Names | Lyt-1, Ly-1, Lymphocyte antigen 1, Ly-12, Ly-A, T1, Tp67 |
| Description | CD5, also known as Lyt-1, is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B-cell antigen CD72. The frequency of CD5+ B cells exhibits strain-dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B-1 cells. Binding of CD5 on the T cell surface can augment alloantigen- or mitogen-induced lymphocyte proliferation and induces increased cytosolic free calcium, IL-2 secretion, and IL-2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T-cell and B-cell receptors. |
| Conjugate | BIOT (Biotin) |
| Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide |
| Clonality | Monoclonal |
| Concentration | 0.5 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C |
| Applications | Flow Cytometry – Quality tested 1 |
| RRID Number | AB_2794858 |
| Gene ID | 12507 (Mouse) |
| Gene ID Symbol | Cd5 (Mouse) |
| Gene ID Aliases | Ly-1; Ly-12; Ly-A; Lyt-1 |
| UniProt ID | P13379 (Mouse |
| UniProt Name | CD5_MOUSE (Mouse) |
Documentation
Certificate of Analysis Lookup
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- 1. Koneru M, Schaer D, Monu N, Ayala A, Frey AB. Defective proximal TCR signaling inhibits CD8+ tumor-infiltrating lymphocyte lytic function. J Immunol. 2005;174:1830-40. (FC)
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