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Mouse Anti-Fibrillin-1-UNLB (11C1.3)
Cat. No.:
1405-01
Purified Anti-Fibrillin-1 antibody for use in immunohistochemistry / immunocytochemistry, electron microscopy, western blot, and immunoprecipitation assays.
$297.00
| Clone | 11C1.3 |
|---|---|
| Isotype | Mouse (BALB/c) IgG1κ |
| Isotype Control | Mouse IgG1-UNLB (15H6) |
| Specificity | Human/Bovine/Japanese Macaque fibrillin-1 |
| Alternative Names | FBN1 |
| Description | The fibrillins are extracellular matrix glycoproteins which occur as a major component of a subset of connective tissue microfibrils. These microfibrils have a beaded appearance and a cross-sectional diameter of 10-12 nm. In elastic tissues, these structures are thought to provide the scaffold onto which elastin is assembled to form elastic fibers, although their function in non-elastic tissues is unclear. There is an aberrant expression of fibrillin in Marfan syndrome. The epitope for the monoclonal antibody 11C1.3 has been found to be within exons 18-20 (a.a. 723-909). |
| Immunogen | Microfibrils from the zonular apparatus of bovine eye |
| Conjugate | UNLB (Unconjugated) |
| Buffer Formulation | Borate buffered saline, pH 8.2 |
| Clonality | Monoclonal |
| Concentration | 0.2 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C |
| Applications | Immunohistochemistry-Frozen Sections – Quality tested 1-8 Immunohistochemistry-Paraffin Sections – Reported in literature 9,10 Immunocytochemistry – Reported in literature 1 Electron Microscopy – Reported in literature 1,2,6 Western Blot – Reported in literature 1 Immunoprecipitation 11 |
| RRID Number | AB_2794754 |
| Gene ID | 2200 (Human) 281154 (Bovine) |
| Gene ID Symbol | FBN1 (Human) FBN1 (Bovine) |
| Gene ID Aliases | FBN; SGS; WMS; MASS; MFLS; MFS1; OCTD; SSKS; WMS2; ACMICD; ECTOL1; GPHYSD2 |
| UniProt ID | P35555 (Human P98133 (Bovine |
| UniProt Name | FBN1_HUMAN (Human) FBN1_BOVIN (Bovine) |
Documentation
Certificate of Analysis Lookup
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- 1. Wright DW, McDaniels CN, Swasdison S, Accavitti MA, Mayne PM, Mayne R. Immunization with undenatured bovine zonular fibrils results in monoclonal antibodies to fibrillin. Matrix Biol. 1994;14:41-49. (Immunogen, IHC-FS, ICC, EM, WB, Bovine & Human Reactivity)
- 2. Maier A, McDaniels CN, Mayne R. Fibrillin and elastin networks in extrafusal tissue and muscle spindles of bovine extraocular muscles. Invest Ophthalmol Vis Sci. 1994;35:3103-10. (IHC-FS, EM, Bovine Reactivity)
- 3. Marionnet C, Vioux-Chagnoleau C, Pierrard C, Sok J, Asselineau D, Bernerd F. Morphogenesis of dermal-epidermal junction in a model of reconstructed skin: beneficial effects of vitamin C. Exp Dermatol. 2006;15:625-33. (IHC-FS, Human Reactivity)
- 4. Pflieger D, Chabane S, Gaillard O, Bernard BA, Ducoroy P, Rossier J, et al. Comparative proteomic analysis of extracellular matrix proteins secreted by two types of skin fibroblasts. Proteomics. 2006;6:5868-79. (IHC-FS, Human Reactivity)
- 5. Sok J, Pineau N, Dalko-Csiba M, Brenton L, Bernerd F. Improvement of the dermal epidermal junction in human reconstructed skin by a new c-xylopyranoside derivative. Eur J Dermatol. 2008;18:297-302. (IHC-FS, Human Reactivity)
- 6. Sawada T. Ultrastructural localization of fibrillin-1 and fibrillin-2 in oxytalan fibers in periodontal ligament of Japanese Macaca fuscata monkey. J Mol Histol. 2010;41:225-31. (IHC-FS, EM, Japanese Macaque Reactivity)
- 7. Grant TM, Thompson MS, Urban J, Yu J. Elastic fibres are broadly distributed in tendon and highly localized around tenocytes. J Anat. 2013;222:573-9. (IHC-FS, Bovine Reactivity)
- 8. Tran C, Michelet JF, Simonetti L, Fiat F, Garrigues A, Potter A, et al. In vitro and in vivo studies with tetra-hydro-jasmonic acid (LR2412) reveal its potential to correct signs of skin ageing. J Eur Acad Dermatol Venereol. 2014;28:415-23. (IHC-FS, Human Reactivity)
- 9. Söderberg MW, Byström B, Hammarström M, Malmström A, Ekman-Ordeberg G. Decreased gene expression of fibrillin-1 in stress urinary incontinence. Neurourol Urodyn. 2010;29:476-81. (IHC-PS, Human Reactivity)
- 10. Qiu SS, Dotor J, Hontanilla B. Effect of P144® (Anti-TGF-β) in an "in vivo" human hypertrophic scar model in nude mice. PLoS One. 2015;10(12):e0144489. (IHC-PS, Human Reactivity)
- 11. Personal communication (IP)
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