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Rat Anti-Mouse LPAM-1-LE/AF (DATK32)
Cat. No.:
1870-14
Low Endotoxin/Azide Free Anti-Mouse LPAM-1 antibody for use in flow cytometry, immunohistochemistry, immunoprecipitation, and blocking assays.
$336.00
| Clone | DATK32 |
|---|---|
| Isotype | Rat (Fischer) IgG2aκ |
| Isotype Control | Rat IgG2a-LE/AF (KLH/G2a-1-1) |
| Specificity | Mouse LPAM-1 |
| Alternative Names | Integrin α4β7, lymphocyte Peyer's patch adhesion molecule |
| Description | The lymphocyte Peyer’s patch adhesion molecule (LPAM-1), also known as integrin α4β7, is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes but is also present on NK cells and eosinophils. The α4β7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM-1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer’s patches and intestinal lamina propria. The monoclonal antibody DATK32 recognizes a conformational epitope on the heterodimer. |
| Immunogen | AKR/Cum mouse T lymphoma cell line TK-1 |
| Conjugate | LE/AF (Low Endotoxin/Azide Free) |
| Buffer Formulation | Phosphate buffered saline, pH 7.4 |
| Clonality | Monoclonal |
| Concentration | 0.5 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C; Handle under aseptic conditions |
| Applications |
Flow Cytometry – Quality tested 1,3-5 Immunohistochemistry-Frozen Sections – Reported in literature 4 Blocking – Reported in literature 1-3 Immunoprecipitation – Reported in literature 4 |
| RRID Number | AB_2795421 |
| Gene ID |
16401 (Mouse) 16421 (Mouse) |
| Gene ID Symbol |
Itga4 (Mouse) Itgb7 (Mouse) |
| Gene ID Aliases | CD49D; Itga4B; Ly69 |
| UniProt ID |
Q00651 (Mouse P26011 (Mouse |
| UniProt Name |
ITA4_MOUSE (Mouse) ITB7_MOUSE (Mouse) |
Documentation
Certificate of Analysis Lookup
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- 1. Andrew DP, Berlin C, Honda S, Yoshino T, Hamann A, Holzmann B, et al. Distinct but overlapping epitopes are involved in α4β7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation. J Immunol. 1994;153:3847-61. (Immunogen, FC, Block)
- 2. Berlin C, Berg EL, Briskin MJ, Andrew DP, Kilshaw PJ, Holzmann B, et al. α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell. 1993;74:185-95. (Block)
- 3. Katayama Y, Hidalgo A, Peired A, Frenette PS. Integrin α4β7 and its counterreceptor MAdCAM-1 contribute to hematopoietic progenitor recruitment into bone marrow following transplantation. Blood. 2004;104:2020-26. (Block, FC)
- 4. Bogetto L, Gabriele E, Cariati R, Dolcetti R, Spressotto P, Doglioni C, et al. Bidirectional induction of the cognate receptor-ligand α4-VCAM-1 pair defines a novel mechanism of tumor intravasation. Blood. 2000;95:2397-406. (FC, IP, IHC-FS)
- 5. Seo G, Jang Y, Kim H, Lee M, Park M, Park S, et al. Retinoic acid, acting as a highly specific IgA isotype switch factor, cooperates with TGF-β1 to enhance the overall IgA response. J Leukoc Biol. 2013;94:325-35. (FC)
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