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Rat Anti-Mouse CD94-PE (18d3)
Cat. No.:
1809-09
PE Anti-Mouse CD94 antibody for use in flow cytometry assays.
$182.00
| Clone | 18d3 |
|---|---|
| Isotype | Rat (Lewis) IgG2aκ |
| Isotype Control | Rat IgG2a-PE (KLH/G2a-1-1) |
| Specificity | Mouse CD94 |
| Alternative Names | Kp43, KLRD1 |
| Description | The monoclonal antibody 18d3 reacts with the mouse CD94 receptor subunit, a type II transmembrane glycoprotein. CD94 is expressed on the surface of NK cells, NK T cells, and some memory phenotype CD8+ cells. When CD94 is paired with NKG2A, C, or E subunit, it binds the nonclassical MHC class Ib molecule Qa-1b and results in a CD94high population by flow cytometry. Approximately half of NK cells do not express NKG2A, C or E; these cells express CD94 on the surface in a form that does not bind Qa-1b and is believed to be nonfunctional, producing a CD94low population by flow cytometry. CD94 is thought to play a role in the adhesion and activation of the NK cell lineage. |
| Immunogen | CHO cells transfected with the B6 allele of CD94 |
| Conjugate | PE (R-phycoerythrin) |
| Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide and a stabilizer |
| Clonality | Monoclonal |
| Concentration | 0.1 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C; Avoid exposure to light; Do not freeze |
| Applications | Flow Cytometry – Quality tested 1-3 |
| RRID Number | AB_2795375 |
| Gene ID | 16643 (Mouse) |
| Gene ID Symbol | Klrd1 (Mouse) |
| Gene ID Aliases | CD94 |
| UniProt ID | O54707 (Mouse |
| UniProt Name | KLRD1_MOUSE (Mouse) |
Documentation
Certificate of Analysis Lookup
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- 1. Vance RE, Jamieson AM, Raulet DH. Recognition of the class Ib molecule Qa-1b by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells. J Exp Med. 1999;190:1801-12. (Immunogen, FC)
- 2. Beyersdorf NB, Ding X, Karp K, Hanke T. Expression of inhibitory "killer cell lectin-like receptor G1" identifies unique subpopulations of effector and memory CD8 T cells. Eur J Immunol. 2001;31:3443-52. (FC)
- 3. Vance RE, Jamieson AM, Cado D, Raulet DH. Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation. Proc Natl Acad Sci USA. 2002;99:868-73. (FC)
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