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Clone | 1G10 |
---|---|
Isotype | Rat (Lewis) IgG2aκ |
Isotype Control | Rat IgG2a-LE/AF (KLH/G2a-1-1) |
Specificity | Mouse CD80 |
Alternative Names | B7-1, Ly-53 |
Description | CD80 (B7-1) is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is constitutively expressed by dendritic cells, monocytes, and peritoneal macrophages. Expression of CD80 on B cells is upregulated after activation by various means including stimulation by LPS, IL-4, and surface Ig receptor crosslinking with peak expression occurring between 48 and 72 hours post-activation. The interaction of CD80 with its ligands, CD28 and CD152 (CTLA-4), provides a potent costimulatory signal for T cells activated through the CD3/T cell receptor complex. The monoclonal antibody 1G10 blocks binding of CTLA-4 to CD80 but it does not block stimulation of T cells by natural antigen-presenting cells. |
Immunogen | Activated 5C2 cells |
Conjugate | LE/AF (Low Endotoxin/Azide Free) |
Buffer Formulation | Phosphate buffered saline, pH 7.4 |
Clonality | Monoclonal |
Concentration | 0.5 mg/mL |
Volume | 1.0 mL |
Recommended Storage | 2-8°C; Handle under aseptic conditions |
Applications |
Flow Cytometry – Quality tested 1-12 Immunoprecipitation – Reported in literature 2 Blocking – Reported in literature 1-3 |
RRID Number | AB_2795210 |
Gene ID |
12519 (Mouse) |
Gene ID Symbol |
Cd80 (Mouse) |
Gene ID Aliases | B71; Ly53; TSA1; Cd28l; Ly-53; MIC17 |
UniProt ID |
Q00609 (Mouse |
UniProt Name |
CD80_MOUSE (Mouse) |
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