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Rat Anti-Mouse CD71-BIOT (RI7217)
Cat. No.:
1720-08
Biotin Anti-Mouse CD71 antibody for use in flow cytometry, immunocytochemistry, western blot, immunoprecipitation, and separation assays.
$303.00
| Clone | RI7217 |
|---|---|
| Isotype | Rat (BDIX) IgG2aκ |
| Isotype Control | Rat IgG2a-BIOT (KLH/G2a-1-1) |
| Specificity | Mouse CD71 |
| Alternative Names | T9, transferrin receptor, TfR |
| Description | CD71, a type II transmembrane glycoprotein expressed on the cell surface as a homodimer, is the transferrin receptor. It is essential for the growth of normal and neoplastic cells. It is expressed at low levels on resting B and T lymphocytes but is upregulated during responses to antigens and mitogens presumably reflecting the iron dependence of proliferation. Its expression declines with maturation and differentiation. CD71 plays a critical role in cell proliferation by controlling the supply of iron which is essential for many metabolic pathways through the binding and endocytosis of transferrin, the major iron-carrying protein. It may also be involved in signal transduction via its association with the T cell receptor ζ chain. The monoclonal antibody RI7217 inhibits cell proliferation in vitro. |
| Immunogen | DMSO induced Friend erythroleukemia 745.6 |
| Conjugate | BIOT (Biotin) |
| Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide |
| Clonality | Monoclonal |
| Concentration | 0.5 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C |
| Applications | Flow Cytometry – Quality tested 1,2,4,5 Immunocytochemistry – Reported in literature 5 Immunoprecipitation – Reported in literature 2 Western Blot – Reported in literature 9 Blocking – Reported in literature 2,3 Separation – Reported in literature 6 Drug Delivery – Reported in literature 7,8 |
| RRID Number | AB_2795192 |
| Gene ID | 22042 (Mouse) |
| Gene ID Symbol | Tfrc (Mouse) |
| Gene ID Aliases | TR; TFR; p90; CD71; TFR1; Trfr; Mtvr1; 2610028K12Rik; E430033M20Rik |
| UniProt ID | Q62351 (Mouse |
| UniProt Name | TFR1_MOUSE (Mouse) |
Documentation
Certificate of Analysis Lookup
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- 1. Lesley J, Hyman R, Schulte R, Trotter J. Expression of transferrin receptor on murine hematopoietic progenitors. Cell Immunol. 1984;83:14-25. (Immunogen, FC)
- 2. Lesley JF, Schulte RJ. Inhibition of cell growth by monoclonal anti-transferrin receptor antibodies. Mol Cell Biol. 1985;5:1814-21. (FC, IP, Block)
- 3. Kemp JD, Thorson JA, Gomez F, Snith KM, Cowdery JS, Ballas ZK. Inhibition of lymphocyte activation with anti-transferrin receptor Mabs: A comparison of three reagents and further studies of their range of effects and mechanism of action. Cell Immunol. 1989;122:218-30. (Block)
- 4. van der Weyden L, Arends MJ, Rust AG, Poulogiannis G, McIntyre RE, Adams DJ. Increased tumorigenesis associated with loss of the tumor suppressor gene Cadm1. Mol Cancer. 2012;11:29. (FC)
- 5. Wang J, Wagner-Britz L, Bogdanova A, Ruppenthal S, Wiesen K, Kaiser E, et al. Morphologically homogeneous red blood cells present a heterogeneous response to hormonal stimulation. PloS One. 2013;8(6):e67697. (ICC, FC)
- 6. Romero JR, Suzuka SM, Nagel RL, Fabry ME. Expression of HbC and HbS, but not HbA, results in activation of K-Cl cotransport activity in transgenic mouse red cells. Blood. 2004;103:2384-90. (Sep)
- 7. Inoue S, Patil R, Portilla-Arias J, Ding H, Konda B, Espinoza A, et al. Nanobiopolymer for direct targeting and inhibition of EGFR expression in triple negative breast cancer. PLoS One. 2012;7(2):e31070. (Drug Delivery)
- 8. Inoue S, Ding H, Portilla-Arias J, Hu J, Konda B, Fujita M, et al. Polymalic acid-based nanobiopolymer provides efficient systemic breast cancer treatment by inhibiting both HER2/neu receptor synthesis and activity. Cancer Res. 2011;71:1454-64. (Drug Delivery)
- 9. Fiani ML, Beitz J, Turvy D, Blum JS, Stahl PD. Regulation of mannose receptor synthesis and turnover in mouse J774 macrophages. J Leukoc Biol. 1998;64:85-91. (WB)
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