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Rat Anti-Mouse CD5-PE (B19.1)
Only %1 left
Cat. No.:
1545-09L,
1545-09
PE Anti-Mouse CD5 antibody for use in flow cytometry assays.
As low as $165.00
| Clone | B19.1 |
|---|---|
| Isotype | Rat IgG2aκ |
| Isotype Control | Rat IgG2a-PE (KLH/G2a-1-1) |
| Specificity | Mouse CD5 |
| Alternative Names | Lyt-1, Ly-1, Lymphocyte antigen 1, Ly-12, Ly-A, T1, Tp67 |
| Description | CD5, also known as Lyt-1, is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B-cell antigen CD72. The frequency of CD5+ B cells exhibits strain-dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B-1 cells. Binding of CD5 on the T cell surface can augment alloantigen- or mitogen-induced lymphocyte proliferation and induces increased cytosolic free calcium, IL-2 secretion, and IL-2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T-cell and B-cell receptors. |
| Conjugate | PE (R-phycoerythrin) |
| Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide and a stabilizer |
| Clonality | Monoclonal |
| Concentration | 0.1 mg/mL |
| Volume | 1.0 mL or 2.0 mL |
| Recommended Storage | 2-8°C; Avoid exposure to light; Do not freeze |
| Applications | Flow Cytometry – Quality tested 1-4 Immunoprecipitation – Reported in literature 5 Western Blot – Reported in literature 5 |
| RRID Number | AB_2794851 |
| Gene ID | 12507 (Mouse) |
| Gene ID Symbol | Cd5 (Mouse) |
| Gene ID Aliases | Ly-1; Ly-12; Ly-A; Lyt-1 |
| UniProt ID | P13379 (Mouse |
| UniProt Name | CD5_MOUSE (Mouse) |
Documentation
Certificate of Analysis Lookup
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- 1. Seagal J, Edry E, Keren Z, Leider N, Benny O, Machluf M, et al. A fail-safe mechanism for negative selection of isotype-switched B cell precursors is regulated by the Fas/FasL pathway. J Exp Med. 2003;198:1609-19. (FC)
- 2. Berge T, Grønningsæter IH, Lorvik KB, Abrahamsen G, Granum S, Sundvold-Gjerstad V, et al. SH2D2A modulates T cell mediated protection to a B cell derived tumor in transgenic mice. PLoS One. 2012;7(10):e48239. (FC)
- 3. Zhu Z, Li R, Li H, Zhou T, Davis RS. FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling. Proc Natl Acad Sci USA. 2013;110:E1282-90. (FC)
- 4. Almena M, Andrada E, Liebana R, Merida I. Diacylglycerol metabolism attenuates T-cell receptor signaling and alters thymocyte differentiation. Cell Death Dis. 2013;4:e912. (FC)
- 5. Personal communication (IP, WB)
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