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Clone | GK1.5 |
---|---|
Isotype | Rat (Lewis) IgG2bκ |
Isotype Control | Rat IgG2b-AF647 (KLH/G2b-1-2) |
Specificity | Mouse CD4 |
Alternative Names | L3T4, Ly-4 |
Description | CD4 is a type I transmembrane glycoprotein expressed on most thymocytes and the helper/inducer subpopulation of mature T lymphocytes of all mouse strains tested. CD4 has also been detected at low density on pluripotent hematopoietic stem cells, bone marrow myeloid precursors, and intrathymic lymphoid precursors. The CD4 antigen functions as a co-receptor, interacting with class II major histocompatability complex (MHC) molecules in the recognition of foreign antigens by T cells. In vivo and in vitro treatment with the GK1.5 monoclonal antibody effectively depletes CD4+ cells. GK1.5 also blocks helper T cell responses to MHC class II antigens, including cytolysis, proliferation, allogeneic B cell help, and release of lymphokines. |
Immunogen | Mouse CTL clone V4 |
Conjugate | AF647 (Alexa Fluor® 647) |
Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide |
Clonality | Monoclonal |
Concentration | 0.5 mg/mL |
Volume | 0.2 mL |
Recommended Storage | 2-8°C; Avoid exposure to light |
Trademark Information | Alexa Fluor® is a registered trademark of Thermo Fisher Scientific, Inc. or its subsidiaries |
Applications |
Flow Cytometry – Quality tested 1,5,7,11-15 Immunohistochemistry-Frozen Sections – Reported in literature 2-4 Immunocytochemistry – Reported in literature 5 Immunoprecipitation – Reported in literature 1 Depletion – Reported in literature 1,7,8 Separation – Reported in literature 6,9,10 Blocking – Reported in literature 1,8 |
RRID Number | AB_2794846 |
Gene ID |
12504 (Mouse) |
Gene ID Symbol |
Cd4 (Mouse) |
Gene ID Aliases | L3T4; Ly-4 |
UniProt ID |
P06332 (Mouse |
UniProt Name |
CD4_MOUSE (Mouse) |
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