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Rat Anti-Mouse CD24-LE/AF (30-F1)
Cat. No.:
1815-14
Low Endotoxin/Azide Free Anti-Mouse CD24 antibody for use in flow cytometry assays.
$330.00
| Clone | 30-F1 |
|---|---|
| Isotype | Rat (LOU/Ws1/M) IgG2cκ |
| Isotype Control | Rat IgG2c-LE/AF (SB68b) |
| Specificity | Mouse CD24 |
| Alternative Names | Heat stable antigen, HSA |
| Description | CD24 is expressed in B cells until their terminal differentiation into plasma cells. It has been used widely as a marker to fractionate different B-lineage differentiation stages. CD24 has been found on a variety of other hematopoietic and neural cell types and is now classified as a costimulatory molecule. The CD24 molecule, also known as HSA, is composed mostly of carbohydrate with a protein core of only 31-35 amino acids in the human and 27 amino acids in the mouse. CD24 is now included in the large group of phosphatidylinositol-anchored membrane proteins. Studies with purified CD24 applied to latex beads have demonstrated a self-binding property suggesting that the molecule is capable of promoting homotypic aggregation, binding, and cell adhesion. This is supported by earlier observations of the blockade of B cell lymphoblast aggregation with an anti-CD24 monoclonal antibody. Recent studies of murine CD24 have assigned a role for CD24 as a ligand for P-selectin, a calcium-dependent lectin. |
| Immunogen | Mouse thymus or spleen |
| Conjugate | LE/AF (Low Endotoxin/Azide Free) |
| Buffer Formulation | Phosphate buffered saline, pH 7.4 |
| Clonality | Monoclonal |
| Concentration | 0.5 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C; Handle under aseptic conditions |
| Applications | Flow Cytometry – Quality tested 1-4 |
| RRID Number | AB_2795392 |
| Gene ID | 12484 (Mouse) |
| Gene ID Symbol | Cd24a (Mouse) |
| Gene ID Aliases | HSA; Cd24; Ly-52; nectadrin |
| UniProt ID | P24807 (Mouse |
| UniProt Name | CD24_MOUSE (Mouse) |
Documentation
Certificate of Analysis Lookup
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- 1. Ledbetter JA, Herzenberg LA. Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. Immunol Rev. 1979;47:63-90. (Immunogen, FC)
- 2. Palmer VL, Kassmeier MD, Willcockson J, Akhter MP, Cullen DM, Swanson PC. N-acetylcysteine increases the frequency of bone marrow pro-B/pre-B cells, but does not reverse cigarette smoking-induced loss of this subset. PLoS One. 2011;6:e24804. (FC)
- 3. Hassaballa AE, Palmer VL, Anderson DK, Kassmeier MD, Nganga VK, Parks KW, et al. Accumulation of B1-like B cells in transgenic mice over-expressing catalytically inactive RAG1 in the periphery. Immunology. 2011;134:469-86. (FC)
- 4. Kassmeier MD, Mondal K, Palmer VL, Ravel P, Kumar S, Perry GA, et al. VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity. EMBO J. 2012;31:945-58. (FC)
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