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Rat Anti-Mouse CD2-LE/AF (12-15)
Cat. No.:
1525-14
Low Endotoxin/Azide Free Anti-Mouse CD2 antibody for use in flow cytometry, immunoprecipitation, blocking, separation, and purification assays.
$281.00
| Clone | 12-15 |
|---|---|
| Isotype | Rat (Sprague Dawley) IgG1κ |
| Isotype Control | Rat IgG1-LE/AF (KLH/G1-2-2) |
| Specificity | Mouse CD2 |
| Alternative Names | LFA-2, T11, Ly37, SRBC-R, Leu-5, LFA-3 receptor |
| Description | CD2, also known as leukocyte function-associated antigen-2 (LFA-2), is a member of the immunoglobulin superfamily of cell adhesion molecules. It is expressed on the surface of >95% of thymocytes, and essentially all B cells, T cells and NK cells. In the mouse, CD2 is the receptor for CD48. CD2 is thought to play a major role in mediating T-cell adhesion, T-cell recognition/activation, T-cell signaling, and intrathymic differentiation. |
| Immunogen | Crude plasma membranes of ESb cells |
| Conjugate | LE/AF (Low Endotoxin/Azide Free) |
| Buffer Formulation | Phosphate buffered saline, pH 7.4 |
| Clonality | Monoclonal |
| Concentration | 0.5 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C; Handle under aseptic conditions |
| Applications | Flow Cytometry – Quality tested 1,7,9 Immunoprecipitation – Reported in literature 1,7 Separation – Reported in literature 2 Blocking – Reported in literature 3-7 Purification – Reported in literature 1,8 |
| RRID Number | AB_2794797 |
| Gene ID | 12481 (Mouse) |
| Gene ID Symbol | Cd2 (Mouse) |
| Gene ID Aliases | Ly37; LFA-2; Ly-37 |
| UniProt ID | P08920 (Mouse |
| UniProt Name | CD2_MOUSE (Mouse) |
Documentation
Certificate of Analysis Lookup
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- 1. Altevogt P, Heckl-Oestreicher G, Lang E, Kohl U, Kratzin H, Schirrmacher V. Murine Fcγ receptor proteins: identification of a previously unrecognized molecule with a monoclonal antibody (12-15). Eur J Immunol. 1988;18:677-83. (Immunogen, FC, Purification, IP)
- 2. Fushimi S, Ogino T, Hara J, Takahata T, Wakabayashi H, Watanabe H, et al. Forced expression of suppressor of cytokine signaling 3 in T cells protects the development of concanavalin A-induced hepatitis in mice. Clin Immunol. 2009;133:437-46. (Sep)
- 3. Bai Y, Liu J, Wang Y, Honig S, Qin L, Boros P, et al. L-selectin-dependent lymphoid occupancy is required to induce alloantigen-specific tolerance. J Immunol. 2002;168:1579-89. (Block)
- 4. Ochando JC, Yoop AC, Yang Y, Garin A, Li Y, Boros P, et al. Lymph node occupancy is required for the peripheral development of alloantigen-specific Foxp3+ regulatory T cells. J Immunol. 2005;174:6993-7005. (Block)
- 5. Qin L, Chavin KD, Lin J, Yagita H, Bromberg JS. Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival. J Exp Med. 1994;179:341-6. (Block)
- 6. Chavin KD, Qin L, Lin J, Woodward JE, Baliga P, Bromberg JS. Combination anti-CD2 and anti-CD3 monoclonal antibodies induce tolerance while altering interleukin-2, interleukin-4, tumor necrosis factor, and transforming growth factor-β production. Ann Surg. 1993;218:492-503. (Block)
- 7. Altevogt P, Kohl U, Von Hoegen P, Lang E, Schirrmacher V. Antibody 12-15 cross-reacts with mouse Fcγ receptors and CD2: study of thymus expression, genetic polymorphism and biosysthesis of the CD2 protein. Eur J Immunol. 1989;19:341-6. (FC, IP, Block)
- 8. Ruppert M, Aigner S, Hubbe M, Yagita H, Altevogt P. The L1 adhesion molecule is a cellular ligand for VLA-5. J Cell Biol. 1995;131:1881-91. (Purification)
- 9. Avagyan S, Glouchkova L, Choi J, Snoeck H. A quantitative trait locus on chromosome 4 affects cycling of hematopoietic stem and progenitor cells through regulation of TGF-β2 responsiveness. J Immunol. 2008;181:5904-11. (FC)
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