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Rat Anti-Mouse CD11a-PE/CY7 (I21/7)
Cat. No.:
1555-17
PE/CY7 Anti-Mouse CD11a antibody for use in flow cytometry assays.
$286.00
| Clone | I21/7 |
|---|---|
| Isotype | Rat (Lewis) IgG2aκ |
| Isotype Control | Rat IgG2a-PE/CY7 (KLH/G2a-1-1) |
| Specificity | Mouse/Human CD11a |
| Alternative Names | LFA-1, LFA-1α, integrin αL |
| Description | The monoclonal antibody I21/7 reacts with the α subunit of mouse and human CD11a, also known as LFA-1, and a member of the integrin family of cell adhesion molecules. The antigen is expressed on thymocytes, T and B lymphocytes, and on non-lymphoid cells in the bone marrow. CD11a appears to be an essential component for T-cell activation by antigen-presenting cells and is important for cell-mediated killing. Costimulatory signaling by LFA-1 is achieved by pairing with its ligand, CD54/ICAM-1. |
| Immunogen | Whole BW5147 cells |
| Conjugate | PE/CY7 (R-phycoerythrin/Cyanine 7) |
| Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide and a stabilizer |
| Clonality | Monoclonal |
| Concentration | 0.1 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C; Avoid exposure to light; Do not freeze |
| Trademark Information | Cy® is a registered trademark of Global Life Sciences Solutions Germany GmbH |
| Applications | Flow Cytometry – Quality tested 5-8 Immunohistochemistry-Frozen Sections – Reported in literature 2 Immunocytochemistry – Reported in literature 3 Immunoprecipitation – Reported in literature 1,4 Blocking – Reported in literature 1 |
| RRID Number | AB_2794895 |
| Gene ID | 16408 (Mouse) 3683 (Human) |
| Gene ID Symbol | Itgal (Mouse) ITGAL (Human) |
| Gene ID Aliases | Cd11a; LFA-1; Ly-15; Ly-21; (p180); LFA-1A; CD11A; LFA1A |
| UniProt ID | P24063 (Mouse P20701 (Human |
| UniProt Name | ITAL_MOUSE (Mouse) ITAL_HUMAN (Human) |
Documentation
Certificate of Analysis Lookup
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- 1. Trowbridge IS, Omary MB. Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1. J Exp Med. 1981;154:1517-24. (Immunogen, IP, Block)
- 2. Pauschinger M, Noutsias M, Lassner D, Schultheiss HP, Kuehl U. Inflammation, ECG changes and pericardial effusion: whom to biopsy in suspected myocarditis?. Clin Res Cardiol. 2006;95:569-83. (IHC-FS, Human Reactivity)
- 3. Thauland TJ, Koguchi Y, Wetzel SA, Dustin ML, Parker DC. Th1 and Th2 cells form morphologically distinct immunological synapses. J Immunol. 2008;181:393-9. (ICC)
- 4. Lefrançois L, Bevan MJ. Novel antigenic determinants of the T200 glycoprotein expressed preferentially by activated cytotoxic T lymphocytes. J Immunol. 1984;135:374-83. (IP)
- 5. Kato N, Yuzawa Y, Kosugi T, Hobo A, Sato W, Miwa Y, et al. The E-selectin ligand basigin/CD147 is responsible for neutrophil recruitment in renal ischemia/reperfusion. J Am Soc Nephrol. 2009;20:1565-76. (FC)
- 6. Takeshi T, Keisuke N, Takaaki I, Makoto Y, Tatsuji N. Involvement of adhesion molecule in in vitro plaque-like formation of macrophages stimulated with Aggregatibacter actinomycetemcomitans lipopolysaccharide. J Periodont Res. 2010;45:550-6. (FC)
- 7. Nagaoka K, Takahara K, Minamino K, Takeda T, Yoshida Y, Inaba K. Expression of C-type lectin, SIGNR3, on subsets of dendritic cells, macrophages, and monocytes. J Leukoc Biol. 2010;88:913-24. (FC)
- 8. Domingos-Pereira S, Decrausaz L, Derré L, Bobst M, Romero P, Schiller JT, et al. Intravaginal TLR agonists increase local vaccine-specific CD8 T cells and human papillomavirus-associated genital-tumor regression in mice. Mucosal Immunol. 2013;6:393-404. (FC)
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