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Rat Anti-Mouse CD107b-APC (ABL-93)
Cat. No.:
1921-11
APC Anti-Mouse CD107b antibody for use in flow cytometry assays.
$212.00
| Clone | ABL-93 |
|---|---|
| Isotype | Rat (Sprague Dawley) IgG2aκ |
| Isotype Control | Rat IgG2a-APC (KLH/G2a-1-1) |
| Specificity | Mouse CD107b |
| Alternative Names | LAMP-2, lysosomal-associated membrane protein 2 |
| Description | CD107b, also known as lysosomal-associated membrane protein 2 (LAMP-2), is a heavily glycosylated type I transmembrane protein that constitutes one of the two major sialoglycoproteins on lysosomal membranes that can be used to distinguish lysosomes from other organelles. CD107b is similar in structure to Mac-1 and is expressed primarily on epithelial cells and macrophages in a variety of organs in normal and beige mutant mice. |
| Immunogen | Glycoproteins purified from BALB/c mouse embryo 3T3 cell line |
| Conjugate | APC (Allophycocyanin) |
| Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide and a stabilizer |
| Clonality | Monoclonal |
| Concentration | 0.1 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C; Avoid exposure to light; Do not freeze |
| Applications |
Flow Cytometry – Quality tested 7 Immunohistochemistry-Frozen Sections – Reported in literature 4 Immunocytochemistry – Reported in literature 1,2,5,6 Electron Microscopy – Reported in literature 1 Immunoprecipitation – Reported in literature 1,2 Western Blot – Reported in literature 2,3 |
| RRID Number | AB_2795537 |
| Gene ID |
16784 (Mouse) |
| Gene ID Symbol |
Lamp2 (Mouse) |
| Gene ID Aliases | CD107b; LGP-B; Lamp II; Lamp-2; Lamp-2a; Lamp-2b; Lamp-2c; Mac3 |
| UniProt ID |
P17047 (Mouse |
| UniProt Name |
LAMP2_MOUSE (Mouse) |
Documentation
Certificate of Analysis Lookup
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- 1. Chen JW, Murphy TL, Willingham MC, Pastan I, August JT. Identification of two lysosomal membrane glycoproteins. J Cell Biol. 1985;101:85-95. (Immunogen, ICC, EM, IP)
- 2. Andrejewski N, Punnonen E, Guhde G, Tanaka Y, Lüllmann-Rauch R, Hartmann D, et al. Normal lysosomal morphology and function in LAMP-1-deficient mice. J Biol Chem. 1999;274:12692-701. (IP, WB, ICC)
- 3. Via LE, Deretic D, Ulmer RJ, Hibler NS, Huber LA, Deretic V. Arrest of mycobacterial phagosome maturation is caused by a block in vesicle fusion between stages controlled by rab5 and rab7. J Biol Chem. 1997;272:13326-31. (WB)
- 4. Zhao W, Dumanis SB, Tamboli IY, Rodriguez GA, LaDu MJ, Moussa CE, et al. Human APOE genotype affects intraneuronal Aβ1-42 accumulation in a lentiviral gene transfer model. Hum Mol Genet. 2014;23:1365-75. (IHC-FS)
- 5. Martina JA, Moriyama K, Bonifacino JS. BLOC-3, a protein complex containing the Hermansky-Pudlak syndrome gene products HPS1 and HPS4. J Biol Chem. 2003;278:29376-84. (ICC)
- 6. Valk E, Leung R, Kang H, Kaneko K, Rudd CE, Schneider H. T cell receptor-interacting molecule acts as a chaperone to modulate surface expression of the CTLA-4 coreceptor. Immunity. 2006;25:807-21. (ICC)
- 7. Ramachandra L, Sramkoski RM, Canaday DH, Boom WH, Harding CV. Flow analysis of MHC molecules and other membrane proteins in isolated phagosomes. J Immunol Methods. 1998;213:53-71. (FC)
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