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Rat Anti-Mouse CD105-PACBLU (MJ7/18)
Cat. No.:
1860-26
Pacific Blue™ Anti-Mouse CD105 antibody for use in flow cytometry assays.
$219.00
| Clone | MJ7/18 |
|---|---|
| Isotype | Rat IgG2aκ |
| Isotype Control | Rat IgG2a-PACBLU (KLH/G2a-1-1) |
| Specificity | Mouse CD105 |
| Alternative Names | Endoglin |
| Description | CD105, also known as endoglin, is a disulfide-linked type II transmembrane homodimer that is predominantly expressed on vascular endothelial cells. It is also found on pre-erythroblasts, macrophages, and lymphoid and myeloid leukemic cells. Both mouse and human CD105 exhibit >70% sequence homology in their cytoplasmic domains with type III transforming growth factor β (TGFβ) receptor. CD105 has been shown to be one of several receptors for the various isoforms of TGFβ which in turn is one of a family of proteins involved in regulation of cell differentiation, migration of cells, and control of the immune response. |
| Immunogen | Inflamed mouse skin |
| Conjugate | PACBLU (Pacific Blue™) |
| Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide |
| Clonality | Monoclonal |
| Concentration | 0.5 mg/mL |
| Volume | 0.2 mL |
| Recommended Storage | 2-8°C; Avoid exposure to light |
| Trademark Information | Pacific Blue™ is a trademark of Thermo Fisher Scientific, Inc. or its subsidiaries |
| Applications |
Flow Cytometry – Quality tested 2,7-9 Immunohistochemistry-Frozen Sections – Reported in literature 6 Immunoprecipitation – Reported in literature 2 Western Blot – Reported in literature 1,2,4,5 Separation – Reported in literature 3 |
| RRID Number | AB_2795412 |
| Gene ID |
13805 (Mouse) |
| Gene ID Symbol |
Eng (Mouse) |
| Gene ID Aliases | Endo; CD105; AI528660; AI662476; S-endoglin |
| UniProt ID |
Q63961 (Mouse |
| UniProt Name |
EGLN_MOUSE (Mouse) |
Documentation
Certificate of Analysis Lookup
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- 1. Ge AZ, Butcher EC. Cloning and expression of a cDNA encoding mouse endoglin, an endothelial cell TGF-β ligand. Gene. 1994;138:201-6. (Immunogen, WB, FC)
- 2. Raab U, Velasco B, Lastres P, LetamendÃa A, Calés C, Langa C, et al. Expression of normal and truncated forms of human endoglin. Biochem J. 1999;339:579-88. (FC, WB, IP)
- 3. Finkensieper A, Kieser S, Bekhite MM, Richter M, Mueller JP, Graebner R, et al. The 5-lipoxygenase pathway regulates vasculogenesis in differentiating mouse embryonic stem cells. Cardiovasc Res. 2010;86:37-44. (Sep)
- 4. Belik J, Jerkic M, McIntyre BA, Pan J, Leen J, Yu LX, et al. Age-dependent endothelial nitric oxide synthase uncoupling in pulmonary arteries of endoglin heterozygous mice. Am J Physiol Lung Cell Mol Physiol. 2009;297:L1170-8. (WB)
- 5. Jerkic M, Peter M, Ardelean D, Fine M, Konerding MA, Letarte M. Dextran sulfate sodium leads to chronic colitis and pathological angiogenesis in endoglin heterozygous mice. Inflamm Bowel Dis. 2010;16:1859-70. (WB)
- 6. Wickersheim A, Kerber M, de Miguel LS, Plate KH, Machein MR. Endothelial progenitor cells do not contribute to tumor endothelium in primary and metastatic tumors. Int J Cancer. 2009;125:1771-7. (IHC-FS)
- 7. Ren Y, Finckenstein FG, Abdueva DA, Shahbazian V, Chung B, Weinberg KI, et al. Mouse mesenchymal stem cells expressing PAX-FKHR form alveolar rhabdomyosarcomas by cooperating with secondary mutations. Cancer Res. 2008;68:6587-97. (FC)
- 8. Adhikari AS, Agarwal N, Wood BM, Porretta C, Ruiz B, Pochampally RR, et al. CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance. Cancer Res. 2010;70:4602-12. (FC)
- 9. Moorthy RK, Sam GA, Kumar SV, Chacko G, Mathews V, Chacko AG, et al. Intralesional mesenchymal stromal cell transplant in a rodent model of cortical cryoinjury. Neurol India. 2011;59:573-8. (FC)
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