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Mouse Anti-Human TLR2-APC (2B4A1)
Cat. No.:
11000-11
APC Anti-Human TLR2 antibody for use in flow cytometry assays.
$352.00
| Clone | 2B4A1 |
|---|---|
| Isotype | Mouse (BALB/c) IgG2aκ |
| Isotype Control | Mouse IgG2a-APC (HOPC-1) |
| Specificity | Human/Canine TLR2 |
| Alternative Names | Toll-like receptor 2, CD282, TIL4 |
| Description | The Toll-like receptor (TLR) family is comprised of type I transmembrane proteins characterized by an extracellular leucine-rich domain and a cytoplasmic tail that contains a conserved region call the Toll/IL-1 (TIR) domain. First discovered in Drosophila, TLRs recognize specific molecular patterns that are present in microbial components and respond to these components in order eliminate or limit invading microbes. TLR2 recognizes and is activated by components from a broad variety of microorganisms including lipoproteins from Gram-negative and Gram-positive bacteria, lipoteichoic acid from Gram-positive bacteria, lipoarabinomannan from mycobacteria, and zymosan from yeast. TLR2 has been reported to functionally associate with TLR1 and TLR6 in order to recognize various lipopeptides. |
| Immunogen | Recombinant TLR2 |
| Conjugate | APC (Allophycocyanin) |
| Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide and a stabilizer |
| Clonality | Monoclonal |
| Concentration | Lot specific |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C; Avoid exposure to light; Do not freeze |
| Applications | Flow Cytometry – Quality tested 1-3 |
| RRID Number | AB_2794568 |
| Gene ID | 7097 (Human) 448807 (Canine) |
| Gene ID Symbol | TLR2 (Human) TLR2 (Canine) |
| Gene ID Aliases | CD282; TIL4 |
| UniProt ID | O60603 (Human Q689D1 (Canine |
| UniProt Name | TLR2_HUMAN (Human) TLR2_CANLF (Canine) |
Documentation
Certificate of Analysis Lookup
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- 1. Amorim IF, Silva SM, Figueiredo MM, Moura EP, Castro RS, Lima TK, et al. Toll receptors type-2 and CR3 expression of canine monocytes and its correlation with immunohistochemistry and xenodiagnosis in visceral leishmaniasis. PLoS One. 2011;6(11):e27679. (FC, Canine Reactivity)
- 2. Rolf N, Kariminia A, Ivison S, Reid GS, Schultz KR. Heterodimer-specific TLR2 stimulation results in divergent functional outcomes in B-cell precursor acute lymphoblastic leukemia. Eur J Immunol. 2015;45:1980-90. (FC)
- 3. Lashkari B, Anumba DO. Estradiol alters the immune-responsiveness of cervical epithelial cells stimulated with ligands of Toll-like receptors 2 and 4. PLoS One. 2017;12(3):e0173646. (FC)
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