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Mouse Anti-Human IL-33-BIOT (SB127j)
Cat. No.:
15710-08
Biotin Anti-Human IL-33 antibody for use in ELISA assays.
$369.00
| Clone | SB127j |
|---|---|
| Isotype | Mouse (BALB/c) IgG2aκ |
| Isotype Control | Mouse IgG2a-BIOT (HOPC-1) |
| Specificity | Human IL-33 |
| Alternative Names | Interleukin-33, IL-1F11, NF-HEV |
| Description | Interleukin-33 (IL-33), also known as NF-HEV, is a 30 kDa protein and a member of the IL-1 family. This pro-inflammatory cytokine is produced by a variety of cells but is primarily expressed by endothelial and smooth muscle cells in the vasculature and airways. IL-33 binds to the ST2 receptor on target cells which results in the activation of multiple signaling pathways including NF-κB and MAP kinases. Studies have shown that IL-33 promotes T helper type 2 (Th2) cell-mediated immune responses and upregulates production of Th2 associated cytokines including IL-4, IL-5, and IL-13. In vivo administration of this cytokine in mice results in eosinophilia and splenomegaly as well as induced severe pathological changes in the lungs, gastrointestinal tract, and other mucosal organs. |
| Immunogen | E. coli-expressed human IL-33 |
| Conjugate | BIOT (Biotin) |
| Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide |
| Clonality | Monoclonal |
| Concentration | 0.5 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C |
| Applications |
ELISA – Quality tested Note – May be paired with the biotinylated clone SB127c (SB Cat. No. 15700-08) in a sandwich ELISA |
| RRID Number | AB_2794946 |
| Gene ID |
90865 (Human) |
| Gene ID Symbol |
IL33 (Human) |
| Gene ID Aliases | C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV |
| UniProt ID |
O95760 (Human |
| UniProt Name |
IL33_HUMAN (Human) |
Documentation
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