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Mouse Anti-Human IL-21-BIOT (SB134f)
Cat. No.:
15910-08
Biotin Anti-Human IL-21 antibody for use in ELISA assays.
$231.00
| Clone | SB134f |
|---|---|
| Isotype | Mouse (BALB/c) IgG2aκ |
| Isotype Control | Mouse IgG2a-BIOT (HOPC-1) |
| Specificity | Human IL-21 |
| Alternative Names | Interleukin-21, Za11 |
| Description | Interleukin-21 (IL-21) is a four helical bundle type I cytokine. The mature form of human IL-21 is a 131 amino acid protein. IL-21 is expressed primarily by NKT and CD4+ T cells, particularly the inflammatory Th17 subset, and has pleiotropic effects on both innate and adaptive immune responses. The effects of IL-21 include promotion of antibody production, NK cell differentiation, proliferation and differentiation of cells of monocyte and granulocyte lineages, costimulation of T cells, and augmentation of antitumor activity of CD8+ T cells. Studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases. |
| Immunogen | E. coli-expressed human IL-21 |
| Conjugate | BIOT (Biotin) |
| Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide |
| Clonality | Monoclonal |
| Concentration | 0.5 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C |
| Applications | ELISA – Quality tested Note – May be paired with the purified clone SB134b (SB Cat. No. 15900-01) in a sandwich ELISA |
| RRID Number | AB_2794998 |
| Gene ID | 59067 (Human) |
| Gene ID Symbol | IL21 (Human) |
| Gene ID Aliases | CVID11; IL-21; Za11 |
| UniProt ID | Q9HBE4 (Human |
| UniProt Name | IL21_HUMAN (Human) |
Documentation
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