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Mouse Anti-Human CD95-SPRD (DX3)
Cat. No.:
9735-13
PE/CY5 (SPRD) Anti-Human CD95 antibody for use in flow cytometry assays.
$303.00
| Clone | DX3 |
|---|---|
| Isotype | Mouse (C3H/He) IgG2aκ |
| Isotype Control | Mouse IgG2a-SPRD (HOPC-1) |
| Specificity | Human/Rat CD95 |
| Alternative Names | APO-1, Fas, TNFRSF6 |
| Description | CD95, also known as Fas and APO-1, is a 45 kDa type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It is expressed by activated lymphocytes, monocytes, neutrophils, fibroblasts, and cell lines. Fas ligand binding to CD95 induces apoptosis in activated mature lymphocytes thereby playing a role in maintaining peripheral tolerance. |
| Immunogen | Human CD95 transfected L cells |
| Conjugate | SPRD (R-phycoerythrin/Cyanine 5) |
| Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide and a stabilizer |
| Clonality | Monoclonal |
| Concentration | Lot specific |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C; Avoid exposure to light; Do not freeze |
| Trademark Information |
Spectral Red® is a registered trademark of Southern Biotechnology Associates, Inc. Spectral Red® is a PE/CY5 tandem conjugate Cy® is a registered trademark of Global Life Sciences Solutions Germany GmbH |
| Applications |
Flow Cytometry – Quality tested 1 Immunohistochemistry-Paraffin Sections – Reported in literature 2,3 ELISA – Reported in literature 4 |
| RRID Number | AB_2797089 |
| Gene ID |
355 (Human) 246097 (Rat) |
| Gene ID Symbol |
FAS (Human) Fas (Rat) |
| Gene ID Aliases | ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6; Tnfrsf6 |
| UniProt ID |
P25445 (Human Q63199 (Rat |
| UniProt Name |
TNR6_HUMAN (Human) TNR6_RAT (Rat) |
Documentation
Certificate of Analysis Lookup
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- 1. Lanier LL, Chang C, Phillips JH. Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes. J Immunol. 1994;153:2417-28. (Immunogen, FC)
- 2. Jacob T, Ascher E, Hingorani A, Kallakuri S. Glycine prevents the induction of apoptosis attributed to mesenteric ischemia/reperfusion injury in a rat model. Surgery. 2003;134:457-66. (IHC-PS, Rat Reactivity)
- 3. Miñambres E, Ballesteros MA, Mayorga M, Marin MJ, Muñoz P, Figols J, et al. Cerebral apoptosis in severe traumatic brain injury patients: an in vitro, in vivo, and postmortem study. J Neurotrauma. 2008;25:581-91. (IHC-PS)
- 4. Jodo S, Kobayashi S, Kayagaki N, Ogura N, Feng Y, Amasaki Y, et al. Serum levels of soluble Fas/APO-1 (CD95) and its molecular structure in patients with systemic lupus erythematosus (SLE) and other autoimmune diseases. Clin Exp Immunol. 1997;107:89-95. (ELISA)
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