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Clone | DX2 |
---|---|
Isotype | Mouse (C3H/He) IgG1κ |
Isotype Control | Mouse IgG1-FITC (15H6) |
Specificity | Human CD95 |
Alternative Names | APO-1, Fas, TNFRSF6 |
Description | CD95, also known as Fas and APO-1, is a 45 kDa type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It is expressed by activated lymphocytes, monocytes, neutrophils, fibroblasts, and cell lines. Fas ligand binding to CD95 induces apoptosis in activated mature lymphocytes thereby playing a role in maintaining peripheral tolerance. Crosslinking of CD95 by the monoclonal antibodies DX2 and DX3 delivers an apoptotic signal to Fas-sensitive cells indicating that these monoclonal antibodies recognize a functional epitope of CD95. |
Immunogen | Human CD95 transfected L cells |
Conjugate | FITC (Fluorescein) |
Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide |
Clonality | Monoclonal |
Concentration | Lot specific |
Volume | 0.25 mL or 1.0 mL |
Recommended Storage | 2-8°C; Avoid exposure to light |
Applications |
Flow Cytometry – Quality tested 1,2,8-15 Immunohistochemistry-Frozen Sections – Reported in literature 2 Immunohistochemistry-Paraffin Sections – Reported in literature 3,4 Immunocytochemistry – Reported in literature 5 Immunoprecipitation – Reported in literature 5,6 ELISA – Reported in literature 7 Apoptosis – Reported in literature 1,8 |
RRID Number | AB_2797075 |
Gene ID |
355 (Human) 574332 (Rhesus) 103216224 (Green Monkey) 105587157 (Sooty Mangabey) |
Gene ID Symbol |
FAS (Human) FAS (Rhesus) FAS (Green Monkey) FAS (Sooty Mangabey) |
Gene ID Aliases | ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6; CD95 |
UniProt ID |
P25445 (Human Q9BDP2 (Rhesus Q9BDN4 (Sooty Mangabey |
UniProt Name |
TNR6_HUMAN (Human) TNR6_MACMU (Rhesus) TNR6_CERAT (Sooty Mangabey) |
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