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Mouse Anti-Human CD8-SPRD (UCHT4)
Cat. No.:
9535-13
PE/CY5 (SPRD) Anti-Human CD8 antibody for use in flow cytometry assays.
$253.00
| Clone | UCHT4 |
|---|---|
| Isotype | Mouse (BALB/c) IgG2aκ |
| Isotype Control | Mouse IgG2a-SPRD (HOPC-1) |
| Specificity | Human/Rhesus/Cynomolgus/Chimpanzee CD8 |
| Alternative Names | Leu-2, Lyt2, Tp32, T8 |
| Description | CD8 is a 33 kDa transmembrane glycoprotein expressed as either a CD8αα homodimer or CD8αβ heterodimer. It is expressed on the “cytotoxic/suppressor” subpopulation of peripheral T cells. CD8 functions primarily as a coreceptor with MHC class I-restricted TCR’s in antigen recognition. |
| Immunogen | Thymocytes and Sézary T cells |
| Conjugate | SPRD (R-phycoerythrin/Cyanine 5) |
| Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide and a stabilizer |
| Clonality | Monoclonal |
| Concentration | Lot specific |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C; Avoid exposure to light; Do not freeze |
| Trademark Information |
Spectral Red® is a registered trademark of Southern Biotechnology Associates, Inc. Spectral Red® is a PE/CY5 tandem conjugate Cy® is a registered trademark of Global Life Sciences Solutions Germany GmbH |
| Applications |
Flow Cytometry – Quality tested 1,2 Immunohistochemistry-Frozen Sections – Reported in literature 3-5 Immunohistochemistry-Paraffin Sections – Reported in literature 6 Immunoprecipitation – Reported in literature 1 Separation – Reported in literature 2 Blocking – Reported in literature 1,7 |
| RRID Number | AB_2796876 |
| Gene ID |
925 (Human) 698329 (Rhesus) 102124337 (Cynomolgus) 735755 (Chimpanzee) |
| Gene ID Symbol |
CD8A (Human) CD8A (Rhesus) CD8A (Cynomolgus) CD8A (Chimpanzee) |
| Gene ID Aliases | CD8; p32; Leu2; CK820_G0032528 |
| UniProt ID |
P01732 (Human |
| UniProt Name |
CD8A_HUMAN (Human) |
Documentation
Certificate of Analysis Lookup
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- 1. Martin PJ, Ledbetter JA, Clark EA, Beatty PG, Hansen JA. Epitope mapping of the human surface suppressor/cytotoxic T cell molecule Tp32. J Immunol. 1984;132:759-65. (FC, IP, Block)
- 2. Satyaraj E, Rath S, Bal V. Induction of tolerance in freshly isolated alloreactive T cells by activated T cell stimulators is not due to the absence of CD28-B7 interaction. J Immunol. 1995;155:4669-75. (FC, Sep)
- 3. Dogan A, Dunn-Walters DK, MacDonald TT, Spencer J. Demonstration of local clonality of mucosal T cells in human colon using DNA obtained by microdissection of immunohistochemically stained tissue sections. Eur J Immunol. 1996;26:1240-5. (IHC-FS)
- 4. Kap YS, van Meurs M, van Driel N, Koopman G, Melief M, Brok HP, et al. A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates. J Histochem Cytochem. 2009;57:1159-67. (IHC-FS, Chimpanzee, Rhesus, Cynomolgus Reactivity)
- 5. Loginov R, Halme L, Arola J, Höckerstedt K, Lautenschlager I. Intragraft immunological events associated with EBV DNAemia in liver transplant patients. APMIS. 2010;118:888-94. (IHC-FS)
- 6. Martín AP, Ortiz S, Cabalier ME, Frede S, Burgos E, Hliba E, et al. Vascular endothelium express CS-1 fibronectin in allergic contact dermatitis. J Cutan Pathol. 2002;29:347-53. (IHC-PS)
- 7. Olsson T, Bakhiet M, Höjeberg B, Ljungdahl Å, Edlund C, Andersson G, et al. CD8 is critically involved in lymphocyte activation by a T. brucei brucei-released molecule. Cell. 1993;72:715-27. (Block)
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