My Quote
You have no items in your quote cart.
Clone | 1.2B6 |
---|---|
Isotype | Mouse (BALB/c) IgG1κ |
Isotype Control | Mouse IgG1-BIOT (15H6) |
Specificity | Human CD62E & CD62P/Porcine CD62E |
Alternative Names | E-selectin, P-selectin, ELAM-1, LECAM-2, PADGEM, GMP-140, LECAM-3 |
Description |
CD62E represents the 97 kDa type I transmembrane glycoprotein E-selectin, also known as endothelial-leukocyte adhesion molecule-1 (ELAM-1). It is expressed on cytokine-stimulated endothelium, weakly on unactivated endothelium, and is absent on leukocytes. Like other selectins, CD62E is an adhesion molecule that contributes to the initial attachment and rolling of leukocytes on endothelial surfaces, a prerequisite for leukocyte extravasation into tissues. CD62P is a 140 kDa membrane glycoprotein formerly known as platelet activation-dependent granule membrane protein (PADGEM) or GMP-140. It is expressed on platelets, megakaryocytes, and epithelium. It is thought to mediate the adhesive interactions of neutrophils and monocytes with endothelium in inflammatory responses and of activated platelets to neutrophils and monocytes in hemostasis. The monoclonal antibody 1.2B6 recognizes a common epitope shared by CD62E and CD62P. |
Immunogen | TNF stimulated human endothelial cells |
Conjugate | BIOT (Biotin) |
Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide |
Clonality | Monoclonal |
Concentration | Lot specific |
Volume | 1.0 mL |
Recommended Storage | 2-8°C |
Applications |
Flow Cytometry – Quality tested 1,2,5,10-17 Immunohistochemistry-Frozen Sections – Reported in literature 4 Immunocytochemistry – Reported in literature 5 Immunoprecipitation – Reported in literature 1 Western Blot-Non-Reducing – Reported in literature 2,3 ELISA – Reported in literature 1,6-8 Blocking – Reported in literature 9,10 Adhesion – Reported in literature 9,10 |
RRID Number | AB_2796817 |
Gene ID |
6401 (Human) 6403 (Human) 397508 (Porcine) |
Gene ID Symbol |
SELE (Human) SELP (Human) SELE (Porcine) |
Gene ID Aliases | CD62E; ELAM; ELAM1; ESEL; LECAM2; CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM; PSEL |
UniProt ID |
P16581 (Human P16109 (Human P98110 (Porcine |
UniProt Name |
LYAM2_HUMAN (Human) LYAM3_HUMAN (Human) LYAM2_PIG (Porcine) |
Enter the Catalog Number and Lot Number for the Certificate of Analysis you wish to view