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Mouse Anti-Human CD55-UNLB (143-30)
Cat. No.:
9661-01
Purified Anti-Human CD55 antibody for use in flow cytometry, immunohistochemistry, western blot, and immunoprecipitation assays.
$114.00
| Clone | 143-30 |
|---|---|
| Isotype | Mouse IgG1κ |
| Isotype Control | Mouse IgG1-UNLB (15H6) |
| Specificity | Human CD55 |
| Alternative Names | DAF, decay accelerating factor |
| Description | CD55, also known as decay accelerating factor (DAF), is an 80 kDa GPI-anchored single chain glycoprotein that is expressed on all cells in contact with serum including all hematopoietic cells and the vascular endothelium. A soluble form of CD55 is present in plasma and body fluids. CD55 is a member of the regulator of complement activity (RCA) family of proteins and is thought to play a role in the protection of cells from damage by autologous complement by preventing the amplification steps of the complement cascade. CD55 expression increases upon T cell activation and antibodies to CD55 are mitogenic in the presence of phorbol esters. |
| Immunogen | PHA activated peripheral blood mononuclear cells |
| Conjugate | UNLB (Unconjugated) |
| Buffer Formulation | Borate buffered saline, pH 8.2 |
| Clonality | Monoclonal |
| Concentration | 0.1 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C |
| Applications | Flow Cytometry – Quality tested 5,6 Immunohistochemistry-Frozen Sections – Reported in literature 1 Immunohistochemistry-Paraffin Sections – Reported in literature 2 Immunoprecipitation – Reported in literature 3 Western Blot-Non-Reducing – Reported in literature 4 |
| RRID Number | AB_2797046 |
| Gene ID | 1604 (Human) |
| Gene ID Symbol | CD55 (Human) |
| Gene ID Aliases | CR; TC; DAF; CROM; CHAPLE |
| UniProt ID | P08174 (Human |
| UniProt Name | DAF_HUMAN (Human) |
Documentation
Certificate of Analysis Lookup
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- 1. Koretz K, Brüderlein S, Henne C, Möller P. Decay-accelerating factor (DAF, CD55) in normal colorectal mucosa, adenomas and carcinomas. Br J Cancer. 1992;66:810-4. (IHC-FS)
- 2. Wu J, Lei L, Wang S, Gu D, Zhang J. Immunohistochemical expression and prognostic value of CD97 and its ligand CD55 in primary gallbladder carcinoma. J Biomed Biotechnol. 2012;2012:587672. (IHC-PS)
- 3. Stefanová I, Hořejší V, Ansotegui IJ, Knapp W, Stockinger H. GPI-anchored cell-surface molecules complexed to protein tyrosine kinases. Science. 1991;254:1016-9. (IP)
- 4. Clayton A, Harris CL, Court J, Mason MD, Morgan BP. Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59. Eur J Immunol. 2003;33:522-31. (WB)
- 5. Zeuke S, Ulmer A, Kusumoto S, Katus HA, Heine H. TLR4-mediated inflammatory activation of human coronary artery endothelial cells by LPS. Cardiovasc Res. 2002;56:126-34. (FC)
- 6. Haas P, Aggermann T, Nagl M, Steindl-Kuscher K, Krugluger W, Binder S. Implication of CD21, CD35, and CD55 in the pathogenesis of age-related macular degeneration. Am J Ophthalmol. 2011;152:396-9. (FC)
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