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Mouse Anti-Human CD49d-UNLB (7.2)
Cat. No.:
9432-01
Purified Anti-Human CD49d antibody for use in flow cytometry, immunocytochemistry, western blot, and immunoprecipitation assays.
$92.00
| Clone | 7.2 |
|---|---|
| Isotype | Mouse IgG1κ |
| Isotype Control | Mouse IgG1-UNLB (15H6) |
| Specificity | Human CD49d |
| Alternative Names | VLA-4, Integrin α4, VLA-4α, ITGA4, IA4 |
| Description | CD49d, a member of the integrin family of extracellular matrix and cell adhesion molecules, is the integrin α4 chain. CD49d associates noncovalently with CD29, the integrin β1 subunit, to form the α4β1 very late antigen-4 (VLA-4) heterodimer. Integrin α4 can also associate with integrin β7 to form the α4β7 heterodimer. It is expressed on most leukocytes with the possible exception of neutrophils. VLA-4 mediates leukocyte binding to CD106 (VCAM-1) and is involved in the migration of leukocytes from blood to tissue at sites of inflammation. VLA-4 can also provide a costimulatory signal to T cells for activation and proliferation. The α4β7 integrin heterodimer is expressed on a small subpopulation of thymocytes, most lymph node T and B lymphocytes, NK cells, and eosinophils. Integrin α4β7 also binds to fibronectin and VCAM-1. |
| Conjugate | UNLB (Unconjugated) |
| Buffer Formulation | Borate buffered saline, pH 8.2 |
| Clonality | Monoclonal |
| Concentration | 0.1 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C |
| Applications | Flow Cytometry – Quality tested 5,6 Immunocytochemistry – Reported in literature 1-3 Immunoprecipitation – Reported in literature 7 Western Blot – Reported in literature 4 |
| RRID Number | AB_2796793 |
| Gene ID | 3676 (Human) |
| Gene ID Symbol | ITGA4 (Human) |
| Gene ID Aliases | CD49D; IA4 |
| UniProt ID | P13612 (Human |
| UniProt Name | ITA4_HUMAN (Human) |
Documentation
Certificate of Analysis Lookup
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- 1. Leitinger B, Hogg N. Effects of I domain deletion on the function of the β2 integrin lymphocyte function-associated antigen-1. Mol Biol Cell. 2000;11:677-90. (ICC)
- 2. Leitinger B, Hogg N. The involvement of lipid rafts in the regulation of integrin function. J Cell Sci. 2002;115:963-72. (ICC)
- 3. Arthos J, Cicala C, Martinelli E, Macleod K, van Ryk D, Wei D, et al. HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells. Nat Immunol. 2008;9:301-9. (ICC)
- 4. McDowall A, Inwald D, Leitinger B, Jones A, Liesner R, Klein N, et al. A novel form of integrin dysfunction involving β1, β2, and β3 integrins. J Clin Invest. 2003;111:51-60. (WB)
- 5. Andersen CA, Handley M, Pollara G, Ridley AJ, Katz DR, Chain BM. β1-Integrins determine the dendritic morphology which enhances DC-SIGN-mediated particle capture by dendritic cells. Int Immunol. 2006;18:1295-1303. (FC)
- 6. Gehwolf R, Band E, Trost A, Iglseder B, Trinka E, Haschke-Becher E, et al. TaqManR proximity ligation technology for the detection of heterodimeric adhesion receptors on lymphocytes. J Immunol Methods. 2014;404:81-6. (FC)
- 7. Personal Communication (IP)
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