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Clone | UCHT1 |
---|---|
Isotype | Mouse (BALB/c) IgG1κ |
Isotype Control | Mouse IgG1-FITC (15H6) |
Specificity | Human CD3 |
Alternative Names | CD3ε, T3E, TCRE, Leu-4, T3 |
Description | CD3, a member of the immunoglobulin superfamily of cell surface receptors, is comprised of five invariable chains ranging from 16-28 kDa and is closely associated with the T cell antigen receptor (TCR). CD3 is expressed on 70-80% of normal peripheral blood lymphocytes and on 10-20% of thymocytes. It plays a major role in signaling during antigen recognition, leading to T cell activation. The monoclonal antibody UCHT1 reacts with the 20 kDa ε chain of the CD3/TCR complex. |
Immunogen | Human peripheral blood lymphocytes from a patient with Sézary's syndrome and infant thymocytes |
Conjugate | FITC (Fluorescein) |
Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide |
Clonality | Monoclonal |
Concentration | Lot specific |
Volume | 0.25 mL or 1.0 mL |
Recommended Storage | 2-8°C; Avoid exposure to light |
Applications |
Flow Cytometry – Quality tested 1,6-11 Immunohistochemistry-Frozen Sections – Reported in literature 4,5 Immunohistochemistry-Paraffin Sections – Reported in literature 5 Immunocytochemistry – Reported in literature 1 Immunoprecipitation – Reported in literature 2 Western Blot – Reported in literature 3 Activation – Reported in literature 1,2 Blocking – Reported in literature 2 |
RRID Number | AB_2796828 |
Gene ID |
916 (Human) |
Gene ID Symbol |
CD3E (Human) |
Gene ID Aliases | T3E; TCRE; IMD18 |
UniProt ID |
P07766 (Human |
UniProt Name |
CD3E_HUMAN (Human) |
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