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Mouse Anti-Human CD25-AF488 (BC96)
Cat. No.:
9582-30
Alexa Fluor® 488 Anti-Human CD25 antibody for use in flow cytometry and immunohistochemistry assays.
$253.00
| Clone | BC96 |
|---|---|
| Isotype | Mouse IgG1κ |
| Isotype Control | Mouse IgG1-AF488 (15H6) |
| Specificity | Human/Rhesus/Cynomolgus CD25 |
| Alternative Names | IL-2Rα, Tac antigen |
| Description | The BC96 monoclonal antibody reacts with human CD25, the 55 kDa interleukin-2 receptor α chain (IL-2Rα). CD25 is expressed by early progenitors of T and B lineage as well as by activated mature T and B lymphocytes. By itself, CD25 binds IL-2 only with low affinity. However, CD25 associates with CD122 (IL-2 receptor β chain) and CD132 (common γ chain) to form the high affinity IL-2 receptor. CD25 plays a role in lymphocyte differentiating and activation/proliferation. CD25 is expressed on activated B cells, monocytes/macrophages, and T cells. |
| Conjugate | AF488 (Alexa Fluor® 488) |
| Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide |
| Clonality | Monoclonal |
| Concentration | Lot specific |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C; Avoid exposure to light |
| Trademark Information | Alexa Fluor® is a registered trademark of Thermo Fisher Scientific, Inc. or its subsidiaries |
| Applications | Flow Cytometry – Quality tested 2,3 Immunohistochemistry-Frozen Sections – Reported in literature 1 |
| RRID Number | AB_2796979 |
| Gene ID | 3559 (Human) 574300 (Rhesus) 102123605 (Cynomolgus) |
| Gene ID Symbol | IL2RA (Human) IL2RA (Rhesus) IL2RA (Cynomolgus) |
| Gene ID Aliases | p55; CD25; IL2R; IMD41; TCGFR; IDDM10; IL-2RA |
| UniProt ID | P01589 (Human Q5MNY4 (Rhesus |
| UniProt Name | IL2RA_HUMAN (Human) IL2RA_MACMU (Rhesus) |
Documentation
Certificate of Analysis Lookup
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- 1. Ernst CW, Lee JE, Nakanishi T, Karimbux NY, Rezende TM, Stashenko P, et al. Diminished forkhead box P3/CD25 double-positive T regulatory cells are associated with the increased nuclear factor-kB ligand (RANKL+) T cells in bone resorption lesion of periodontal disease. Clin Exp Immunol. 2007;148:271-80. (IHC-FS)
- 2. Cornwell WD, Lewis MG, Fan X, Rappaport J, Rogers TJ. Effect of chronic morphine administration on circulating T cell population dynamics in rhesus macaques. J Neuroimmunol. 2013;265:43-50. (FC, Rhesus Reactivity)
- 3. Willer DO, Ambagala AP, Pilon R, Chan JK, Fournier J, Brooks J, et al. Experimental infection of Cynomolgus Macaques (Macaca fascicularis) with human varicella-zoster virus. J Virol. 2012;86:3626-34. (FC, Cynomolgus Reactivity)
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