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Mouse Anti-Human CD23-UNLB (Tü1)
Cat. No.:
9580-01
Purified Anti-Human CD23 antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blot, and blocking assays.
$114.00
| Clone | Tü1 |
|---|---|
| Isotype | Mouse IgG3κ |
| Isotype Control | Mouse IgG3-UNLB (B10) |
| Specificity | Human CD23 |
| Alternative Names | FCεRII, B6, Leu-20, BLAST-2, low affinity IgE receptor |
| Description | CD23 is a 45 kDa type II integral membrane glycoprotein that is the low affinity receptor for IgE. It also binds to CD21 and the α chains of CD11b and CD11c. It is expressed by B cells and monocytes and, weakly, on T cells, follicular dendritic cells, eosinophils, NK cells, Langerhans cells, and platelets. It is upregulated in response to B cell activation, CD40 ligation, or in response to IL-4 or IL-13. CD23 is responsible for regulation of IgE synthesis and may play a role in antigen presentation by B cells and follicular dendritic cells by interacting with CD40. |
| Immunogen | KR3598 cells |
| Conjugate | UNLB (Unconjugated) |
| Buffer Formulation | Borate buffered saline, pH 8.2 |
| Clonality | Monoclonal |
| Concentration | 0.1 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C |
| Applications |
Flow Cytometry – Quality tested 2-5 Immunohistochemistry-Frozen Sections – Reported in literature 1,6,7 Immunocytochemistry – Reported in literature 7,8 Western Blot – Reported in literature 7,9,10 Blocking – Reported in literature 7 |
| RRID Number | AB_2796970 |
| Gene ID |
2208 (Human) |
| Gene ID Symbol |
FCER2 (Human) |
| Gene ID Aliases | BLAST-2; CD23; CD23A; CLEC4J; FCE2; IGEBF |
| UniProt ID |
P06734 (Human |
| UniProt Name |
FCER2_HUMAN (Human) |
Documentation
Certificate of Analysis Lookup
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- 1. Ziegler A, Stein H, Müller C, Wernet P. Tü1: a monoclonal antibody defining a B cell subpopulation - usefulness for the classificaton of non-Hodgkin's lymphomas. In: Knapp W, editor. Leukemia Markers: Proceedings of the Leukemia Marker Conference held in Vienna, February 15-18, 1981. London: Academic Press; 1981. p. 113-6. (Immunogen, IHC-FS)
- 2. Sallusto F, Cella M, Danieli C, Lanzavecchia A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J Exp Med. 1995;182:389-400. (FC)
- 3. Del Giudice I, Matutes E, Morilla R, Morilla A, Owusu-Ankomah K, Rafiq F, et al. The diagnostic value of CD123 in B-cell disorders with hairy or villous lymphocytes. Haematologica. 2004;89:303-8. (FC)
- 4. Johnson SE, Shah N, Panoskaltsis-Mortari A, LeBien TW. Murine and human IL-7 activate STAT5 and induce proliferation of normal human pro-B cells. J Immunol. 2005;175:7325-31. (FC)
- 5. Vaisitti T, Gaudino F, Ouk S, Moscvin M, Vitale N, Serra S, et al. Targeting metabolism and survival in chronic lymphocytic leukemia and Richter syndrome cells by a novel NF-κB inhibitor. Haematologica. 2017;102:1878-89. (FC)
- 6. Hermes B, Worm M, Nowak F, Kroczek RA, Stein H, Henz BM. Upregulation of CD40 and CD40 ligand expression in IgE-associated cutaneous diseases. Acta Derm Venereol. 1997;77:441-5. (IHC-FS)
- 7. Tu Y, Salim S, Bourgeois J, Di Leo V, Irvine EJ, Marshall JK, et al. CD23-mediated IgE transport across human intestinal epithelium: inhibition by blocking sites of translation or binding. Gastroenterology. 2005;129:928-40. (IHC-FS, ICC, WB, Block)
- 8. Mason DY, Comans-Bitter WM, Cordell JL, Verhoeven MJ, van Dongen JJ. Antibody L26 recognizes an intracellular epitope on the B-cell-associated CD20 antigen. Am J Pathol. 1990;136:1215-22. (ICC)
- 9. Tu Y, Perdue MH. CD23-mediated transport of IgE/immune complexes across human intestinal epithelium: role of p38 MAPK. Am J Physiol Gastrointest Liver Physiol. 2006;291:G532-8. (WB)
- 10. Tu Y, Oluwole C, Struiksma S, Perdue MH, Yang PC. Mast cells modulate transport of CD23/IgE/antigen complex across human intestinal epithelial barrier. N Am J Med Sci. 2009;1:16-24. (WB)
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