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Hamster Anti-Mouse Ly-49C/F/H/I-UNLB (14B11)
Cat. No.:
1801-01
Purified Anti-Mouse Ly-49C/F/H/I antibody for use in flow cytometry and cytotoxicity assays.
$218.00
| Clone | 14B11 |
|---|---|
| Isotype | Hamster (Syrian) IgG1 |
| Isotype Control | Hamster IgG-UNLB |
| Specificity | Mouse Ly-49C/F/H/I |
| Alternative Names | Ly-49 |
| Description | The monoclonal antibody 14B11 reacts with murine Ly49C, Ly49F, Ly49H, and Ly49I, members of the lectin-like homodimeric Ly49 family of cell surface receptors. Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells while allowing them to attack infected or transformed cells in which class I molecules have been downregulated. These inhibitory receptors are also expressed on a subpopulation of mouse CD8+ T cells. The 14B11 antibody stains ~90% of NK1.1+CD3- splenocytes and ~6% of CD8+ spleen cells from C57BL/6 mice. The antibody also stains 30-80% of NK1.1+CD3- splenocytes in other mouse strains tested (BALB/c, C3H, 129, SJL, AKR/J). |
| Immunogen | IL-2 activated natural killed (A-LAK) cells from C57BL/6 mice |
| Conjugate | UNLB (Unconjugated) |
| Buffer Formulation | Borate buffered saline, pH 8.2 |
| Clonality | Monoclonal |
| Concentration | 0.5 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C |
| Applications |
Flow Cytometry – Quality tested 1,2 Cytoxicity – Reported in literature 1 |
| RRID Number | AB_2795327 |
| Gene ID |
16634 (Mouse) 16637 (Mouse) 16639 (Mouse) 16640 (Mouse) |
| Gene ID Symbol |
Klra3 (Mouse) Klra6 (Mouse) Klra8 (Mouse) Klra9 (Mouse) |
| Gene ID Aliases | 5E6; Ly49c; NK-2.1; Nk-2; Nk2; Nk2.1; Ly49f; ly-49f; Cmv-1; Cmv1; Ly49h; Ly49u<129>; LY49I1; Ly49I |
| UniProt ID |
Q64329 (Mouse Q60653 (Mouse Q60682 (Mouse Q2TJJ8 (Mouse |
| UniProt Name |
KLRA3_MOUSE (Mouse) KLRA6_MOUSE (Mouse) KLRA8_MOUSE (Mouse) Q2TJJ8_MOUSE (Mouse) |
Documentation
Certificate of Analysis Lookup
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- 1. Corral L, Takizawa H, Hanke T, Jamieson AM, Raulet DH. A new monoclonal antibody reactive with several Ly49 NK cell receptors mediates redirected lysis of target cells. Hybridoma. 1999;18:359-66. (Immunogen, Cyto, FC)
- 2. Chung JW, Kim MS, Piao Z, Jeong M, Yoon SR, Shin N, et al. Osteopontin promotes the development of natural killer cells from hematopoietic stem cells. Stem Cells. 2008;26:2114-23. (FC)
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