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Hamster Anti-Mouse CD3ε-LE/AF (500-A2)
Cat. No.:
1531-14
Low Endotoxin/Azide Free Anti-Mouse CD3 epsilon antibody for use in flow cytometry, immunohistochemistry, immunoprecipitation, and activation assays.
$218.00
| Clone | 500-A2 |
|---|---|
| Isotype | Hamster (Syrian) IgG2 |
| Isotype Control | Hamster IgG-LE/AF |
| Specificity | Mouse CD3ε |
| Alternative Names | CD3 epsilon |
| Description | CD3ε, a member of the immunoglobulin superfamily of cell surface receptors, is comprised of five invariable chains ranging in size from 16-28 kDa and is closely associated with the T cell antigen receptor (TCR). CD3ε is expressed on all T cells of all mouse strains. CD3 plays a major role in signaling during antigen recognition, leading to T-cell activation. 500-A2 recognizes an epitope on the 25 kDa ε chain of the CD3/TCR complex of mouse strains tested. |
| Immunogen | Immune complexes isolated from C6VL-BS thymoma cells |
| Conjugate | LE/AF (Low Endotoxin/Azide Free) |
| Buffer Formulation | Phosphate buffered saline, pH 7.4 |
| Clonality | Monoclonal |
| Concentration | 0.5 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C; Handle under aseptic conditions |
| Applications | Flow Cytometry – Quality tested 1 Immunohistochemistry-Frozen Sections – Reported in literature 3 Immunoprecipitation – Reported in literature 1 Activation – Reported in literature 1,2,4 |
| RRID Number | AB_2794815 |
| Gene ID | 12501 (Mouse) |
| Gene ID Symbol | Cd3e (Mouse) |
| Gene ID Aliases | AI504783; CD3; CD3epsilon; T3e |
| UniProt ID | P22646 (Mouse |
| UniProt Name | CD3E_MOUSE (Mouse) |
Documentation
Certificate of Analysis Lookup
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- 1. Allison JP, Havran WL, Poenie M, Kimura J, DeGraffenreid L, Ajami M, et al. Expression and function of CD3 on murine thymocytes. In: Davis MM, Kappler J, editors. The T-Cell Receptor, UCLA Symposia, 73rd Edition. New York: Alan R. Liss; 1988. p.33-45. (Immunogen, FC, IP, Activ)
- 2. Swallow MM, Wallin JJ, Sha WC. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFα. Immunity. 1999;11:423-32. (Activ)
- 3. Hörnquist CE, Lu X, Rogers-Fani PM, Rudolph U, Shappell S, Birnbaumer L, et al. Gαi2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines. J Immunol. 1997;158:1068-77. (IHC-FS)
- 4. Portoles P, Rojo J, Golby A, Bonneville M, Gromkowski S, Greenbaum L, et al. Monoclonal antibodies to murine CD3ε define distinct epitopes one of which may interact with CD4 during T cell activation. J Immunol. 1989;142:4169-75. (Activ)
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