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Hamster Anti-Mouse CD30-BIOT (mCD30.1)
Cat. No.:
1620-08
Biotin Anti-Mouse CD30 antibody for use in flow cytometry assays.
$281.00
| Clone | mCD30.1 |
|---|---|
| Isotype | Hamster (Armenian) IgG1 |
| Isotype Control | Hamster IgG-BIOT |
| Specificity | Mouse CD30 |
| Alternative Names | Ki-1, Ber-H2 |
| Description | CD30 is a type I transmembrane protein and a member of the tumor necrosis factor receptor superfamily of proteins. Murine CD30 is expressed predominantly in the thymus and it is inducible in mouse splenocytes stimulated with pokeweed mitogen or concanavalin A. In anti-CD3ε-activated spleen cells, CD30 is expressed primarily on the surface of CD8+ T cells with peak expression on days 4 and 5. Stimulation of CD30+ CTL lines with plate-bound anti-CD30 directly signals IL-5 but not IFN-γ production. While these studies demonstrate that CD30 directs cytokine secretion and suggest that CD30 may play a pivotal role in the pattern of cytokine production by T cells, the precise roles of CD30 and its ligand (CD153) in T-cell development have not been clearly defined. |
| Immunogen | Mouse CD30-mouse IgG1 fusion protein |
| Conjugate | BIOT (Biotin) |
| Buffer Formulation | Phosphate buffered saline containing < 0.1% sodium azide |
| Clonality | Monoclonal |
| Concentration | 0.5 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C |
| Applications | Flow Cytometry – Quality tested 1 Stimulation – Reported in literature 1,2 Costimulation – Reported in literature 1 Blocking – Reported in literature 3 |
| RRID Number | AB_2795039 |
| Gene ID | 21941 (Mouse) |
| Gene ID Symbol | Tnfrsf8 (Mouse) |
| Gene ID Aliases | Ki; Cd30; Ki-1; D1S166E |
| UniProt ID | Q60846 (Mouse |
| UniProt Name | TNR8_MOUSE (Mouse) |
Documentation
Certificate of Analysis Lookup
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- 1. Bowen MA, Lee RK, Miragliotta G, Nam SY, Podack ER. Structure and expression of murine CD30 and its role in cytokine production. J Immunol. 1996;156:442-9. (Immunogen, FC, Stim, Costim)
- 2. Sun X, Yamada H, Shibata K, Muta H, Tani K, Podack ER, et al. CD30 ligand/CD30 plays a critical role in Th17 differentiation in mice. J Immunol. 2010;185:2222-30. (Stim)
- 3. Polte T, Behrendt A, Hansen G. Direct evidence for a critical role of CD30 in the development of allergic asthma. J Allergy Clin Immunol. 2006;118:942-8. (Block)
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