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Mouse Anti-Chicken TCR γδ

ANTIGEN DESCRIPTION
MAb TCR1 precipitates a heterodimer of Mr 90-kDa (two bands of Mr 40-kDa and 50-kDa upon reduction) on chicken peripheral blood T cells.[1,2] Deglycosylation of the heterodimer yields two polypeptides of Mr 35-kDa and 32-kDa from TCR1 precipitates. Unlike human and mouse, in which γδ cells comprise a minor subset of T lymphocytes in the circulation, the chicken has a relatively large subset of γδ T cells.[1-3] The frequency of TCRγδ cells is usually 20-25% of the total blood T cells, but may reach approximately 50% in chickens of 6 months of age.[2] The majority of TCRγδ+ cells in the thymus and blood are CD4- CD8- , although a small subset of them may express CD8 or CD4 coreceptors.[3] However, when the TCRγδ+ cells migrate into the spleen and intestine, most of them begin to express CD8. Although the biological function of γδ T cells is unclear, they are clearly capable of cytotoxic activity in vitro. The CD8+ γδ T cells may also be involved in down-regulation of the immune response.[4] They cannot, however, induce a graft-vs-host (GVH) reactions.[5]
[Technical Bulletin / References ] Back to CD Markers and Other Cell Surface Proteins Product List
 Cat. No.Product DescriptionCloneSize
USD Price
Order Qty
8230-01
 
Mouse Anti-Chicken TCRgd-UNLB
TCR-1 0.5 mg
$240.00
8230-02
 
Mouse Anti-Chicken TCRgd-FITC
TCR-1 0.5 mg
$340.00
8230-08
 
Mouse Anti-Chicken TCRgd-BIOT
TCR-1 0.5 mg
$305.00
8230-09
 
Mouse Anti-Chicken TCRgd-R-PE
TCR-1 0.1 mg
$215.00
FORMAT ABBREVIATIONS:
UNLB - purified, unlabeled antibody
FITC - fluorescein isothiocyanate-labeled
TRITC - tetramethlyrhodamine isothiocyanate
AP - alkaline phosphatase-labeled
HRP - horseradish peroxidase-labeled
BGAL - B-galactosidase-labeled
TXRD - Texas RedTM
BIOT - biotin-labeled
R-PE - R-phycoerythrin-labeled
R-PE/TXRD - R-phycoerythrin/Texas RedTM
APC - allophycocyanin
 CY3 - CyanineTM 3-labeled *
SPRD - SpectralRedTM-labeled *
LE/AF - low endotoxin/azide-free
CY5 - CyanineTM5-labeled *
R-PE/CY5.5 - R-phycoerythrin/CyanineTM5.5-labeled *
R-PE/CY7 - R-phycoerythrin/CyanineTM7-labeled *
APC/CY5.5 - allophycocyanin/CyanineTM5.5-labeled *
APC/CY7 - allophycocyanin/CyanineTM7-labeled *
FLMA - fluorescein-5-malemide-labeled
SEPH - sepharose-labeled
BIMA - biotin-maleimide-labeled
NOTE: *SpectralRedTM (SPRD) is a tandem conjugate of R-phycoerythrin and CYTM5. It was developed as a reagent for 3-color flow cytometry on instruments with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.