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Rat Anti-Mouse MadCAM-1

ANTIGEN DESCRIPTION
Mucosal vascular addressin-1 (MAdCAM-1) is a type I transmembrane glycoprotein expressed at high levels on high endothelial venules (HEV) of Peyer’s patches and mesenteric lymph nodes, and on flatwalled venules within the gut lamina propria. It is also expressed on sinus-lining cells in the spleen.[1-3] The countereceptor or “homing receptor” for MAdCAM-1 is α4β7 integrin (also known as LPAM-1). MAdCAM-1 is also a facultative ligand for CD62L/L-selectin.[4,5] The monoclonal antibody MECA-367 binds to the first domain of MAdCAM-1 and blocks MAdCAM-1-dependent binding in vitro and lymphocyte homing to Peyer’s patch HEV in vivo.[1,2,4]
[Technical Bulletin / References ] Back to CD Markers and Other Cell Surface Proteins Product List
 Cat. No.Product DescriptionCloneSize
USD Price
Order Qty
1865-01
 
Rat Anti-Mouse MAdCAM-1-UNLB
MECA-367 0.5 mg
$218.00
1865-02
 
Rat Anti-Mouse MAdCAM-1-FITC
MECA-367 0.5 mg
$300.00
1865-08
 
Rat Anti-Mouse MAdCAM-1-BIOT
MECA-367 0.5 mg
$235.00
1865-14
 
Rat Anti-Mouse MAdCAM-1-LE/AF
MECA-367 0.5 mg
$275.00
FORMAT ABBREVIATIONS:
UNLB - purified, unlabeled antibody
FITC - fluorescein isothiocyanate-labeled
TRITC - tetramethlyrhodamine isothiocyanate
AP - alkaline phosphatase-labeled
HRP - horseradish peroxidase-labeled
BGAL - B-galactosidase-labeled
TXRD - Texas RedTM
BIOT - biotin-labeled
R-PE - R-phycoerythrin-labeled
R-PE/TXRD - R-phycoerythrin/Texas RedTM
APC - allophycocyanin
 CY3 - CyanineTM 3-labeled *
SPRD - SpectralRedTM-labeled *
LE/AF - low endotoxin/azide-free
CY5 - CyanineTM5-labeled *
R-PE/CY5.5 - R-phycoerythrin/CyanineTM5.5-labeled *
R-PE/CY7 - R-phycoerythrin/CyanineTM7-labeled *
APC/CY5.5 - allophycocyanin/CyanineTM5.5-labeled *
APC/CY7 - allophycocyanin/CyanineTM7-labeled *
FLMA - fluorescein-5-malemide-labeled
SEPH - sepharose-labeled
BIMA - biotin-maleimide-labeled
NOTE: *SpectralRedTM (SPRD) is a tandem conjugate of R-phycoerythrin and CYTM5. It was developed as a reagent for 3-color flow cytometry on instruments with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.