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Mouse Anti-Mouse CD45.1 (Ly-5.1)

ANTIGEN DESCRIPTION
The CD45 antigen is an essential regulator of leukocyte activation and development, and is now known to be a protein tyrosine phosphatase, e.g. CD45 is able to dephosphorylate the Src family of protein kinases.[1,2] This activity is now known to be required for signal transduction induced by T and B cell antigen receptor engagement, cytokine signaling and Fc receptor stimulation.[1,2] The functional state of CD45 also has a pronounced effect on lymphocyte development. CD45 exists in multiple forms, such as the restricted variants (CD45R; see companion products 1660, 1665, 1675, 1685 and 1820) and as allelic forms CD45.1/Ly-5.1 and CD45.2/Ly-5.2. The former arises as a result of alternative splicing of different exons. The specificity of antibodies to CD45.1 and CD45.2 has been exploited in studies where resolution of donor and recipient cells is essential, such as in gene therapy or bone marrow transplantation.[3,4] The monoclonal antibody A20 recognizes all mouse leukocytes expressing the CD 45.1 allotype.
[Technical Bulletin / References ] Back to CD Markers and Other Cell Surface Proteins Product List
 Cat. No.Product DescriptionCloneSize
USD Price
Order Qty
1795-01
 
Mouse Anti-Mouse CD45.1/Ly-5.1-UNLB
A20 0.5 mg
$212.00
1795-02
 
Mouse Anti-Mouse CD45.1/Ly-5.1-FITC
A20 0.5 mg
$245.00
1795-08
 
Mouse Anti-Mouse CD45.1/Ly-5.1-BIOT
A20 0.5 mg
$222.00
1795-09
 
Mouse Anti-Mouse CD45.1/Ly-5.1-R-PE
A20 0.1 mg
$175.00
1795-09L
 
Mouse Anti-Mouse CD45.1/Ly-5.1-R-PE
A20 0.2 mg
$260.00
1795-11
 
Mouse Anti-Mouse CD45.1/Ly-5.1-APC
A20 0.1 mg
$212.00
1795-13
 
Mouse Anti-Mouse CD45.1/Ly-5.1-SPRD
A20 0.1 mg
$245.00
1795-15
 
Mouse Anti-Mouse CD45.1/Ly-5.1-CY5
A20 0.1 mg
$250.00
1795-16
 
Mouse Anti-Mouse CD45.1/Ly-5.1-PE/CY5.5
A20 0.1 mg
$285.00
1795-17
 
Mouse Anti-Mouse CD45.1/Ly-5.1-PE/CY7
A20 0.1 mg
$188.00
1795-18
 
Mouse Anti-Mouse CD45.1/Ly5.1-APC/CY5.5
A20 0.1 mg
$205.00
1795-19
 
Mouse Anti-Mouse CD45.1/Ly-5.1-APC/CY7
A20 0.1 mg
$225.00
1795-26
 
Mouse Anti-Mouse CD45.1/Ly5.1-Pacific Blue
A20 0.1 mg
$190.00
1795-30
 
Mouse Anti-Mouse CD45.1/Ly5.1-Alexa Fluor 488
A20 0.1 mg
$190.00
1795-31
 
Mouse Anti-Mouse CD45.1/Ly5.1-Alexa Fluor 647
A20 0.1 mg
$190.00
FORMAT ABBREVIATIONS:
UNLB - purified, unlabeled antibody
FITC - fluorescein isothiocyanate-labeled
TRITC - tetramethlyrhodamine isothiocyanate
AP - alkaline phosphatase-labeled
HRP - horseradish peroxidase-labeled
BGAL - B-galactosidase-labeled
TXRD - Texas RedTM
BIOT - biotin-labeled
R-PE - R-phycoerythrin-labeled
R-PE/TXRD - R-phycoerythrin/Texas RedTM
APC - allophycocyanin
 CY3 - CyanineTM 3-labeled *
SPRD - SpectralRedTM-labeled *
LE/AF - low endotoxin/azide-free
CY5 - CyanineTM5-labeled *
R-PE/CY5.5 - R-phycoerythrin/CyanineTM5.5-labeled *
R-PE/CY7 - R-phycoerythrin/CyanineTM7-labeled *
APC/CY5.5 - allophycocyanin/CyanineTM5.5-labeled *
APC/CY7 - allophycocyanin/CyanineTM7-labeled *
FLMA - fluorescein-5-malemide-labeled
SEPH - sepharose-labeled
BIMA - biotin-maleimide-labeled
NOTE: *SpectralRedTM (SPRD) is a tandem conjugate of R-phycoerythrin and CYTM5. It was developed as a reagent for 3-color flow cytometry on instruments with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.