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Rat Anti-Mouse CD22 (Lyb-8)

ANTIGEN DESCRIPTION
CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression.[1,2] CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion.[2-4] Its intracellular domain is phosphorylated after antigen receptor crosslinking and is involved in negative regulation of B-cell activation.[6-9]
[Technical Bulletin / References ] Back to CD Markers and Other Cell Surface Proteins - Mouse
 Cat. No.Product DescriptionCloneSize
USD Price
Order Qty
1580-01
 
Rat Anti-Mouse CD22-UNLB
2D6 0.5 mg
$245.00
1580-02
 
Rat Anti-Mouse CD22-FITC
2D6 0.5 mg
$295.00
1580-08
 
Rat Anti-Mouse CD22-BIOT
2D6 0.5 mg
$280.00
1580-09
 
Rat Anti-Mouse CD22-R-PE
2D6 0.1 mg
$185.00
1580-11
 
Rat Anti-Mouse CD22-APC
2D6 0.1 mg
$222.00
1580-13
 
Rat Anti-Mouse CD22-SPRD
2D6 0.1 mg
$225.00
1580-14
 
Rat Anti-Mouse CD22-LE/AF
2D6 0.5 mg
$320.00
FORMAT ABBREVIATIONS:
UNLB - purified, unlabeled antibody
FITC - fluorescein isothiocyanate-labeled
TRITC - tetramethlyrhodamine isothiocyanate
AP - alkaline phosphatase-labeled
HRP - horseradish peroxidase-labeled
BGAL - B-galactosidase-labeled
TXRD - Texas RedTM
BIOT - biotin-labeled
R-PE - R-phycoerythrin-labeled
R-PE/TXRD - R-phycoerythrin/Texas RedTM
APC - allophycocyanin
 CY3 - CyanineTM 3-labeled *
SPRD - SpectralRedTM-labeled *
LE/AF - low endotoxin/azide-free
CY5 - CyanineTM5-labeled *
R-PE/CY5.5 - R-phycoerythrin/CyanineTM5.5-labeled *
R-PE/CY7 - R-phycoerythrin/CyanineTM7-labeled *
APC/CY5.5 - allophycocyanin/CyanineTM5.5-labeled *
APC/CY7 - allophycocyanin/CyanineTM7-labeled *
FLMA - fluorescein-5-malemide-labeled
SEPH - sepharose-labeled
BIMA - biotin-maleimide-labeled
NOTE: *SpectralRedTM (SPRD) is a tandem conjugate of R-phycoerythrin and CYTM5. It was developed as a reagent for 3-color flow cytometry on instruments with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.