Javascript Menu by Deluxe-Menu.com

Rat Anti-Mouse CD8α (Ly-2)

ANTIGEN DESCRIPTION
In the mouse, CD8 exists in two forms: (i) a CD8 heterodimer composed of an α chain (CD8α/Lyt-2) and a β chain (CD8β/Lyt-3); and (ii) a homodimer of two α chains. The heterodimer is found on the surface of essentially all thymocytes and the “suppressor/cytotoxic” subpopulation of mature T lymphocytes. Subsets of intestinal intraepithelial lymphocytes express CD8α without CD8β. It has been suggested that CD8+β- T cells mature extrathymically, while development of the CD8α+β+ population of T cells is thymus-dependent. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC class I-restricted CD8+ T cells. In vivo and in vitro treatment with the 53-6.[7] monoclonal antibody effectively depletes CD8α+ cells. The 53-6.[7] monoclonal antibody also blocks allogeneic help specific for class I MHC antigens and T cell responses to IL-2. [1-8]
[Technical Bulletin / References ] Back to CD Markers and Other Cell Surface Proteins - Mouse
 Cat. No.Product DescriptionCloneSize
USD Price
Order Qty
1550-01
 
Rat Anti-Mouse CD8a/Ly-2-UNLB
53-6.7 0.5 mg
$158.00
1550-02
 
Rat Anti-Mouse CD8a/Ly-2-FITC
53-6.7 0.5 mg
$212.00
1550-02S
 
Rat Anti-Mouse CD8a/Ly-2-FITC
53-6.7 0.1 mg
$75.00
1550-08
 
Rat Anti-Mouse CD8a/Ly-2-BIOT
53-6.7 0.5 mg
$192.00
1550-09
 
Rat Anti-Mouse CD8a/Ly-2-R-PE
53-6.7 0.1 mg
$90.00
1550-09L
 
Rat Anti-Mouse CD8a/Ly-2-R-PE
53-6.7 0.2 mg
$142.00
1550-10
 
Rat Anti-Mouse CD8a/Ly-2-PE/TXRD
53-6.7 0.1 mg
$255.00
1550-11
 
Rat Anti-Mouse CD8a/Ly-2-APC
53-6.7 0.1 mg
$222.00
1550-13
 
Rat Anti-Mouse CD8a/Ly-2-SPRD
53-6.7 0.1 mg
$177.00
1550-14
 
Rat Anti-Mouse CD8a/Ly-2-LE/AF
53-6.7 0.5 mg
$192.00
1550-15
 
Rat Anti-Mouse CD8a/Ly-2-CY5
53-6.7 0.1 mg
$250.00
1550-16
 
Rat Anti-Mouse CD8a/Ly-2-PE/CY5.5
53-6.7 0.1 mg
$195.00
1550-17
 
Rat Anti-Mouse CD8a/Ly-2-PE/CY7
53-6.7 0.1 mg
$177.00
1550-18
 
Rat Anti-Mouse CD8a-Ly-2-APC/CY5.5
53-6.7 0.1 mg
$290.00
1550-19
 
Rat Anti-Mouse CD8a/Ly-2-APC/CY7
53-6.7 0.1 mg
$192.00
1550-30
 
Rat Anti-Mouse CD8a/Ly-2-Alexa Fluor 488
53-6.7 0.1 mg
$192.00
1550-31
 
Rat Anti-Mouse CD8a/Lyt-2-Alexa Fluor 647
53-6.7 0.1 mg
$192.00
FORMAT ABBREVIATIONS:
UNLB - purified, unlabeled antibody
FITC - fluorescein isothiocyanate-labeled
TRITC - tetramethlyrhodamine isothiocyanate
AP - alkaline phosphatase-labeled
HRP - horseradish peroxidase-labeled
BGAL - B-galactosidase-labeled
TXRD - Texas RedTM
BIOT - biotin-labeled
R-PE - R-phycoerythrin-labeled
R-PE/TXRD - R-phycoerythrin/Texas RedTM
APC - allophycocyanin
 CY3 - CyanineTM 3-labeled *
SPRD - SpectralRedTM-labeled *
LE/AF - low endotoxin/azide-free
CY5 - CyanineTM5-labeled *
R-PE/CY5.5 - R-phycoerythrin/CyanineTM5.5-labeled *
R-PE/CY7 - R-phycoerythrin/CyanineTM7-labeled *
APC/CY5.5 - allophycocyanin/CyanineTM5.5-labeled *
APC/CY7 - allophycocyanin/CyanineTM7-labeled *
FLMA - fluorescein-5-malemide-labeled
SEPH - sepharose-labeled
BIMA - biotin-maleimide-labeled
NOTE: *SpectralRedTM (SPRD) is a tandem conjugate of R-phycoerythrin and CYTM5. It was developed as a reagent for 3-color flow cytometry on instruments with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.