Mouse Anti-Human Akt (PKB)
Akt, also known as protein kinase B (PKB), is a 57 kDa serine/threonine protein kinase. There are three mammalian isoforms of Akt: Akt1 (PKBα), Akt2 (PKBβ) and Akt3 (PKBγ) with Akt2 and Akt3 being approximately 82% identical with the Akt1 isoform. Each isoform has a pleckstrin homology (PH) domain, a kinase domain and a carboxy-terminal regulatory domain. Atk is a downstream target of phosphatidylinositol 3-kinase (PI-3K) activation through the phosphorylation of Atk at two residues following the interaction of 3’-phosphorylated phosphoinositides, such as PtdIns(3,4)P2 and PtdIns (3,4,5)P3, via PH domains. Atk has been shown to play a role in such metabolic processes as glucose transport, glycogen synthesis, glycolysis, and protein synthesis. It had also been shown to promote cell survival by inhibiting apoptosis through its ability to phosphoylate and inactivate several targets, including Bad, Forkhead transcription factors, and caspase-9.
[Technical Bulletin / References ]
View Products by Category
We currently do not have items matching your search request.
Please try another search or see our
Products by Category
for assistance with your search.
- purified, unlabeled antibody
- fluorescein isothiocyanate-labeled
- tetramethlyrhodamine isothiocyanate
- alkaline phosphatase-labeled
- horseradish peroxidase-labeled
- Texas Red
- R-phycoerythrin/Texas Red
- low endotoxin/azide-free
(SPRD) is a tandem conjugate of R-phycoerythrin and CY
5. It was developed as a reagent for 3-color flow cytometry on instruments with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.
Request 2013 Catalog
Terms and Conditions
Customer & Technical Service: 1-800-722-2255 (USA & Canada), 1-205-945-1774, Fax: 1-205-945-8768
Copyright © 2013 SouthernBiotech