Mouse Anti-Cytokeratin 8
Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1-8). The two keratin types share only 30% sequence homology.
Keratins demonstrate tissue- and differentiation-specific expression profiles. Cytokeratin 8 (55 kDa) belongs to the type B (basic) subfamily of high molecular weight keratins and exists in combination with keratin 18. It is expressed in all simple type epithelia tissues (e.g., liver, pancreas, kidney, gut epithelial lining) but not in stratified squamous epithelia. Cytokeratin 8 is also present in the majority of adenocarcinomas and ductal carcinomas but is absent in squamous cell carcinomas.
The SB37b monoclonal antibody reacts specifically with cytokeratin 8 and recombinant C-terminal keratin 8.
[Technical Bulletin / References ]
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Mouse Anti-Cytokeratin 8-UNLB
Mouse Anti-Cytokeratin 8-FITC
Mouse Anti-Cytokeratin 8-HRP
- purified, unlabeled antibody
- fluorescein isothiocyanate-labeled
- tetramethlyrhodamine isothiocyanate
- alkaline phosphatase-labeled
- horseradish peroxidase-labeled
- Texas Red
- R-phycoerythrin/Texas Red
- low endotoxin/azide-free
(SPRD) is a tandem conjugate of R-phycoerythrin and CY
5. It was developed as a reagent for 3-color flow cytometry on instruments with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.
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