Mouse Anti-Human Bcl-xL
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ANTIGEN DESCRIPTION
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Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems.[2] It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment.[3] Bcl- 2 and one of its homologues, Bcl-xL, protect cells from apoptosis[4,5] , while other homologues of Bcl-2 such as Bax, Bad and Bak have been shown to enhance apoptosis.[6-9] Bcl-xL has been shown to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2.[10-14] In contrast, Bad and Bax inhibit the protective functions of Bcl-xL and Bcl-2, respectively. Although heterodimerization between Bcl-xL/Bad and Bcl-2/Bax was originally thought to be essential for the differential anti-apoptotic activity of Bcl-xL and Bcl-2, [5,14] other results suggest that the formation of heterodimers may not be necessary for this death-repressing activity.[16,17]
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| Cat. No. | Product Description | Clone | Size |
USD Price
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Order Qty
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10035-01
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Mouse Anti-Bcl-xL-UNLB
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2H12
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0.1 mg
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$185.00
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FORMAT ABBREVIATIONS:
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UNLB - purified, unlabeled antibody
FITC - fluorescein isothiocyanate-labeled
TRITC - tetramethlyrhodamine isothiocyanate
AP - alkaline phosphatase-labeled
HRP - horseradish peroxidase-labeled
BGAL - B-galactosidase-labeled
TXRD - Texas RedTM
BIOT - biotin-labeled
R-PE - R-phycoerythrin-labeled
R-PE/TXRD - R-phycoerythrin/Texas RedTM
APC - allophycocyanin
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CY3 - CyanineTM 3-labeled *
SPRD - SpectralRedTM-labeled *
LE/AF - low endotoxin/azide-free
CY5 - CyanineTM5-labeled *
R-PE/CY5.5 - R-phycoerythrin/CyanineTM5.5-labeled *
R-PE/CY7 - R-phycoerythrin/CyanineTM7-labeled *
APC/CY5.5 - allophycocyanin/CyanineTM5.5-labeled *
APC/CY7 - allophycocyanin/CyanineTM7-labeled *
FLMA - fluorescein-5-malemide-labeled
SEPH - sepharose-labeled
BIMA - biotin-maleimide-labeled
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NOTE: *SpectralRedTM (SPRD) is a tandem conjugate of R-phycoerythrin and
CYTM5. It was developed as a reagent for 3-color flow cytometry on instruments
with only 488 nm excitation source. It requires minimal (0-2%) FL2/FL3 compensation.
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